Background/Aim: In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. Materials and Methods: Primary and secondary endpoints of this prospective observational study were local control and safety related to IG-SBRT. All lesions were treated with 24 Gy as a single fraction or 27 Gy in 3 fractions. After SBRT, Systemic therapies were administered only after the occurrence of more than three synchronous active lesions in oligometastatic patients (patients with less than 4 active synchronous lesions) or new lesions occurrence in patients with more than 3 synchronous lesions. Results: From April 2011 to June 2017, 78 metastatic lesions (32 bone and 46 node) from 51 patients with prostate cancer were treated. After a median follow-up of 18.5 months (range=3-103 months), only 2 lesions (4%) relapsed inside the radiation field. All local recurrences were located on the bone. Estimated 12 and 24 months local control ratios were 98.7 and 97.4%, respectively. Except for one case, toxicity greater than G2 was not recorded. Conclusion: IG-SBRT is safe and can be considered as a valid therapy in patients with metastatic prostate cancer requiring a long-lasting metastases control.

Pasqualetti, F., Panichi, M., Sainato, A., Baldaccini, D., Cocuzza, P., Gonnelli, A., et al. (2018). Image-guided stereotactic body radiotherapy in metastatic prostate cancer. ANTICANCER RESEARCH, 38(5), 3119-3122 [10.21873/anticanres.12572].

Image-guided stereotactic body radiotherapy in metastatic prostate cancer

Erba P. A.
Penultimo
;
2018

Abstract

Background/Aim: In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. Materials and Methods: Primary and secondary endpoints of this prospective observational study were local control and safety related to IG-SBRT. All lesions were treated with 24 Gy as a single fraction or 27 Gy in 3 fractions. After SBRT, Systemic therapies were administered only after the occurrence of more than three synchronous active lesions in oligometastatic patients (patients with less than 4 active synchronous lesions) or new lesions occurrence in patients with more than 3 synchronous lesions. Results: From April 2011 to June 2017, 78 metastatic lesions (32 bone and 46 node) from 51 patients with prostate cancer were treated. After a median follow-up of 18.5 months (range=3-103 months), only 2 lesions (4%) relapsed inside the radiation field. All local recurrences were located on the bone. Estimated 12 and 24 months local control ratios were 98.7 and 97.4%, respectively. Except for one case, toxicity greater than G2 was not recorded. Conclusion: IG-SBRT is safe and can be considered as a valid therapy in patients with metastatic prostate cancer requiring a long-lasting metastases control.
Articolo in rivista - Articolo scientifico
Image guided radiotherapy; Metastatic prostate cancer; Oligometastatic patients; Stereotactic body radiotherapy;
English
2018
38
5
3119
3122
reserved
Pasqualetti, F., Panichi, M., Sainato, A., Baldaccini, D., Cocuzza, P., Gonnelli, A., et al. (2018). Image-guided stereotactic body radiotherapy in metastatic prostate cancer. ANTICANCER RESEARCH, 38(5), 3119-3122 [10.21873/anticanres.12572].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/419751
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