The impact of breast surgery on survival of metastatic breast cancer (MBC) patients is controversial. We addressed the question in a mono-institutional series of MBC patients with synchronous bone metastases. We identified 187 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) MBC, synchronous bone metastases, with no other distant sites being involved. Progression-free survival (PFS) and overall survival (OS) were compared between operated and non-operated patients. Median age was 51 years; 92 % of the women had a hormone-positive tumor. At the time of diagnosis, 131 patients out of 187 (70 %) underwent surgery. Operated and non-operated patients differed in terms of number of bone metastatic sites: a single metastasis was detected in 35 (28 %) operated, and 6 (11 %) non-operated cases (P = 0.01). No other significant differences were observed. The multi-adjusted hazard ratio was 0.63 (95 % CI 0.43-0.92) for PFS and 0.64 (95 % CI 0.41-0.99) for OS in favor of surgery. The 5-year cumulative incidence of ipsilateral breast skin progressions among non-operated patients was 18 %. In this large and homogeneous series of MBC patients with synchronous bone metastases, the role of breast surgery had a favorable impact on both disease progression and mortality.

Botteri, E., Munzone, E., Intra, M., Bagnardi, V., Rotmensz, N., Bazolli, B., et al. (2013). Role of breast surgery in T1-3 breast cancer patients with synchronous bone metastases. BREAST CANCER RESEARCH AND TREATMENT, 138(1), 303-310 [10.1007/s10549-013-2449-6].

Role of breast surgery in T1-3 breast cancer patients with synchronous bone metastases

BAGNARDI, VINCENZO;
2013

Abstract

The impact of breast surgery on survival of metastatic breast cancer (MBC) patients is controversial. We addressed the question in a mono-institutional series of MBC patients with synchronous bone metastases. We identified 187 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) MBC, synchronous bone metastases, with no other distant sites being involved. Progression-free survival (PFS) and overall survival (OS) were compared between operated and non-operated patients. Median age was 51 years; 92 % of the women had a hormone-positive tumor. At the time of diagnosis, 131 patients out of 187 (70 %) underwent surgery. Operated and non-operated patients differed in terms of number of bone metastatic sites: a single metastasis was detected in 35 (28 %) operated, and 6 (11 %) non-operated cases (P = 0.01). No other significant differences were observed. The multi-adjusted hazard ratio was 0.63 (95 % CI 0.43-0.92) for PFS and 0.64 (95 % CI 0.41-0.99) for OS in favor of surgery. The 5-year cumulative incidence of ipsilateral breast skin progressions among non-operated patients was 18 %. In this large and homogeneous series of MBC patients with synchronous bone metastases, the role of breast surgery had a favorable impact on both disease progression and mortality.
Articolo in rivista - Articolo scientifico
Advanced breast cancer; Synchronous metastasis;Surgery;Survival
English
2013
138
1
303
310
none
Botteri, E., Munzone, E., Intra, M., Bagnardi, V., Rotmensz, N., Bazolli, B., et al. (2013). Role of breast surgery in T1-3 breast cancer patients with synchronous bone metastases. BREAST CANCER RESEARCH AND TREATMENT, 138(1), 303-310 [10.1007/s10549-013-2449-6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/41862
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