Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus (HC) of mice co-treated chronically with MTEP and NS398 (a COX-2 inhibitor). We found both antidepressant-like effects and cognitive to be associated with mGlu7 receptor-mediated mechanisms.

Stachowicz, K., Sowa-Kucma, M., Panczyszyn-Trzewik, P., Misztak, P., Marciniak, M., Bobula, B., et al. (2021). Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2. NEUROSCIENCE LETTERS, 741(10 January 2021) [10.1016/j.neulet.2020.135435].

Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2

Misztak P.;
2021

Abstract

Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus (HC) of mice co-treated chronically with MTEP and NS398 (a COX-2 inhibitor). We found both antidepressant-like effects and cognitive to be associated with mGlu7 receptor-mediated mechanisms.
Articolo in rivista - Articolo scientifico
COX-2; mGluR7; Modified Barnes maze; TST;
English
7-nov-2020
2021
741
10 January 2021
135435
none
Stachowicz, K., Sowa-Kucma, M., Panczyszyn-Trzewik, P., Misztak, P., Marciniak, M., Bobula, B., et al. (2021). Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2. NEUROSCIENCE LETTERS, 741(10 January 2021) [10.1016/j.neulet.2020.135435].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/418538
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