Obstructive sleep apnoea (OSA) is the most common sleep disorder of breathing in middleaged and overweight subjects. It features recurrent episodes of upper airway total (apnoea) o partial (hypopnea) collapse during sleep, which are associated with a reduction in blood oxygen saturation and with arousal from sleep to re-establish airway patency. An association of OSA with dysregulation of the autonomous nervous system (ANS) and altered catecholamines (CAs) metabolism has been contended for years. However, the pathophysiology mechanisms underlying these alterations remain to be fully clarified. Nonetheless, these alterations are deemed to play a key pathogenic role in the established association of OSA with several conditions besides arterial hypertension (HT), including coronary artery disease, stroke, and, more in general, with increased risk of cardiovascular (CV) events. Hence, in this review we will analyse the relationship between the sleep disturbances associated with OSA and the altered function of the ANS, including CAs metabolism.

Bisogni, V., Pengo, M., Maiolino, G., Rossi, G. (2016). The sympathetic nervous system and catecholamines metabolism in obstructive sleep apnoea. JOURNAL OF THORACIC DISEASE, 8(2), 243-254 [10.3978/j.issn.2072-1439.2015.11.14].

The sympathetic nervous system and catecholamines metabolism in obstructive sleep apnoea

Pengo M;
2016

Abstract

Obstructive sleep apnoea (OSA) is the most common sleep disorder of breathing in middleaged and overweight subjects. It features recurrent episodes of upper airway total (apnoea) o partial (hypopnea) collapse during sleep, which are associated with a reduction in blood oxygen saturation and with arousal from sleep to re-establish airway patency. An association of OSA with dysregulation of the autonomous nervous system (ANS) and altered catecholamines (CAs) metabolism has been contended for years. However, the pathophysiology mechanisms underlying these alterations remain to be fully clarified. Nonetheless, these alterations are deemed to play a key pathogenic role in the established association of OSA with several conditions besides arterial hypertension (HT), including coronary artery disease, stroke, and, more in general, with increased risk of cardiovascular (CV) events. Hence, in this review we will analyse the relationship between the sleep disturbances associated with OSA and the altered function of the ANS, including CAs metabolism.
Articolo in rivista - Review Essay
Cardiovascular risk (CV risk); Catecholamines (CAs); Obstructive sleep apnoea (OSA); Sympathetic nervous system (SNS);
English
2016
8
2
243
254
none
Bisogni, V., Pengo, M., Maiolino, G., Rossi, G. (2016). The sympathetic nervous system and catecholamines metabolism in obstructive sleep apnoea. JOURNAL OF THORACIC DISEASE, 8(2), 243-254 [10.3978/j.issn.2072-1439.2015.11.14].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/417001
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