(Figure Presented) Innovative mimics of lipid A were synthesized and shown to efficiently inhibit lipid A induced cytokine production in human dendritic cells and macrophages. These compounds, which consist of a D-glucose unit functionalized with an amine, ammonium, or hydroxylamine group and a five-membered ring at C6 (see structures) are promising leads for antisepsis-drug development owing to their lack of toxicity and their selectivity for the TLR4 receptor. © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.
Peri, F., Granucci, F., Costa, B., Zanoni, I., Marinzi, C., Nicotra, F. (2007). Inhibition of lipid A stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 46(18), 3308-3312 [10.1002/anie.200604932].
Inhibition of lipid A stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides
PERI, FRANCESCO;GRANUCCI, FRANCESCA;COSTA, BARBARA SIMONA;ZANONI, IVAN;NICOTRA, FRANCESCO
2007
Abstract
(Figure Presented) Innovative mimics of lipid A were synthesized and shown to efficiently inhibit lipid A induced cytokine production in human dendritic cells and macrophages. These compounds, which consist of a D-glucose unit functionalized with an amine, ammonium, or hydroxylamine group and a five-membered ring at C6 (see structures) are promising leads for antisepsis-drug development owing to their lack of toxicity and their selectivity for the TLR4 receptor. © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.
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