(Figure Presented) Innovative mimics of lipid A were synthesized and shown to efficiently inhibit lipid A induced cytokine production in human dendritic cells and macrophages. These compounds, which consist of a D-glucose unit functionalized with an amine, ammonium, or hydroxylamine group and a five-membered ring at C6 (see structures) are promising leads for antisepsis-drug development owing to their lack of toxicity and their selectivity for the TLR4 receptor. © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.

Peri, F., Granucci, F., Costa, B., Zanoni, I., Marinzi, C., & Nicotra, F. (2007). Inhibition of lipid A stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 46(18), 3308-3312 [10.1002/anie.200604932].

Inhibition of lipid A stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides

PERI, FRANCESCO;GRANUCCI, FRANCESCA;COSTA, BARBARA SIMONA;ZANONI, IVAN;NICOTRA, FRANCESCO
2007

Abstract

(Figure Presented) Innovative mimics of lipid A were synthesized and shown to efficiently inhibit lipid A induced cytokine production in human dendritic cells and macrophages. These compounds, which consist of a D-glucose unit functionalized with an amine, ammonium, or hydroxylamine group and a five-membered ring at C6 (see structures) are promising leads for antisepsis-drug development owing to their lack of toxicity and their selectivity for the TLR4 receptor. © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.
No
Articolo in rivista - Articolo scientifico
Scientifica
biological activity, carbohydrates, drug design, immunology, medicinal chemistry
English
3308
3312
5
Peri, F., Granucci, F., Costa, B., Zanoni, I., Marinzi, C., & Nicotra, F. (2007). Inhibition of lipid A stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 46(18), 3308-3312 [10.1002/anie.200604932].
Peri, F; Granucci, F; Costa, B; Zanoni, I; Marinzi, C; Nicotra, F
File in questo prodotto:
File Dimensione Formato  
angewandte.pdf

Solo gestori archivio

Dimensione 568.22 kB
Formato Adobe PDF
568.22 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/4161
Citazioni
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 30
Social impact