AIM: To examine the acute actions of the CB1 cannabinoid receptor antagonist SR141716A [N-piperidino-5-(4-chlorophenyl)- 1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide] on typical behavioral pattern of psychoactive cannabinoids in rats. METHODS: At different time after injection the tail-flick response latency, the rectal temperature, the locomotor activity, and the immobility on a ring as well as the numbers of rears, self-grooming episodes (lasting 5 s), and fecal pellets were measured. RESULTS: Acute administration of SR141716A (3 mg/kg i.p.) induced a significant increase in horizontal locomotor activity assayed by an activity meter, in stereotypic activity (such as rearing and self-grooming) and in defecation, and a decrease in nociceptive threshold recorded as tail-flick latency. This dose had no effect on ring immobility and did not change the body temperature. CONCLUSION: These results demonstrate that this cannabinoid antagonist itself was inducing behavior opposite to that of CB1 receptor agonists

Costa, B., Colleoni, M. (1999). SR141716A induces in rats a behavioral pattern opposite to that of CB1 receptor agonists. ACTA PHARMACOLOGICA SINICA, 20(12), 1103-1108.

SR141716A induces in rats a behavioral pattern opposite to that of CB1 receptor agonists

COSTA, BARBARA SIMONA;
1999

Abstract

AIM: To examine the acute actions of the CB1 cannabinoid receptor antagonist SR141716A [N-piperidino-5-(4-chlorophenyl)- 1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide] on typical behavioral pattern of psychoactive cannabinoids in rats. METHODS: At different time after injection the tail-flick response latency, the rectal temperature, the locomotor activity, and the immobility on a ring as well as the numbers of rears, self-grooming episodes (lasting 5 s), and fecal pellets were measured. RESULTS: Acute administration of SR141716A (3 mg/kg i.p.) induced a significant increase in horizontal locomotor activity assayed by an activity meter, in stereotypic activity (such as rearing and self-grooming) and in defecation, and a decrease in nociceptive threshold recorded as tail-flick latency. This dose had no effect on ring immobility and did not change the body temperature. CONCLUSION: These results demonstrate that this cannabinoid antagonist itself was inducing behavior opposite to that of CB1 receptor agonists
Articolo in rivista - Articolo scientifico
SR141716, cannabinoids, pain measurement
English
1103
1108
6
Costa, B., Colleoni, M. (1999). SR141716A induces in rats a behavioral pattern opposite to that of CB1 receptor agonists. ACTA PHARMACOLOGICA SINICA, 20(12), 1103-1108.
Costa, B; Colleoni, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/4158
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