The objective of this study was to investigate whether single and repeated administration of the cannabinoids anandamide or Delta(9)-tetrahydrocannabinol affected brain energetic metabolism. Single administration of either anandamide (20 mg/kg) or Delta(9)-tetrahydrocannabinol (10 mg/kg) in rats induced a behaviour typical with cannabinoids. An increase in both brain mitochondria oxidative phosphorylation and cerebral lipoperoxidation was shown ex vivo. The cannabinoid CB1 receptor-specific antagonist, N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide (SR141716A; 3 mg/kg), reversed the anandamide-induced metabolic effects. Prolonged exposure to anandamide (20 mg/kg, 16 days) induced behavioural tolerance and the disappearance of the increased mitochondria oxygen uptake and lipoperoxidation. Repeated Delta(9)-tetrahydrocannabinol injection (10 mg/kg, twice daily, 4.5 days) reduced brain metabolism and uncoupled respiration from oxidative phosphorylation. The present findings showed that both anandamide and Delta(9)-tetrahydrocannabinol enhanced the energetic brain metabolism, probably via the cannabinoid CB1 receptor; the anandamide-tolerant brain of rats showed tolerance to the drug for metabolic effects, while the brain of Delta(9)-tetrahydrocannabinol-tolerant rats showed metabolic signs of neuronal damage, i.e. low energy production
Costa, B., & Colleoni, M. (2000). Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol. EUROPEAN JOURNAL OF PHARMACOLOGY, 395(1), 1-7 [10.1016/S0014-2999(00)00170-9].
Citazione: | Costa, B., & Colleoni, M. (2000). Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol. EUROPEAN JOURNAL OF PHARMACOLOGY, 395(1), 1-7 [10.1016/S0014-2999(00)00170-9]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol | |
Autori: | Costa, B; Colleoni, M | |
Autori: | ||
Data di pubblicazione: | 2000 | |
Lingua: | English | |
Rivista: | EUROPEAN JOURNAL OF PHARMACOLOGY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0014-2999(00)00170-9 | |
Appare nelle tipologie: | 01 - Articolo su rivista |