Background: Recent studies using quantitative methods, such as principal component factor analysis, hierarchical cluster analysis and latent class analysis have suggested that Gilles de la Tourette syndrome (GTS) should no longer be considered a unitary condition as in current classification systems. Objective: To identify quantitative components of GTS symptomatology using a large, well characterised cohort of singleton individuals with GTS in order to inform future genetic studies with more homogeneous phenotypes. Methods: Principal component factor analysis with oblique rotation was used to analyse symptom data from a sample of 639 patients recruited at two tertiary referral centres using identical schedules during the period 1980-2008. Results: Three Factors were identified: (1) complex motor tics and echo-paliphenomena; (2) attention deficit and hyperactivity symptoms plus aggressive behaviours; and (3) complex vocal tics and coprophenomena. Obsessive compulsive behaviours loaded significantly on the first two factors. The three factors accounted for 48.5% of the total symptomatic variance. Conclusions: GTS is a phenotypically heterogeneous condition encompassing simple tics, specific complex tics and associated behavioural problems. The results, coupled with previous findings, identified a clinical continuum of complex tics, hyperactivity/impulsivity symptoms and semantically relevant utterances and gestures. A better characterisation of the GTS phenotypes will help to identify susceptibility genes.

Cavanna, A., Critchley, H., Orth, M., Stern, J., Young, M., Robertson, M. (2011). Dissecting the Gilles de la Tourette spectrum: A factor analytic study on 639 patients. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 82(12), 1320-1323 [10.1136/jnnp.2010.225029].

Dissecting the Gilles de la Tourette spectrum: A factor analytic study on 639 patients

Cavanna A;
2011

Abstract

Background: Recent studies using quantitative methods, such as principal component factor analysis, hierarchical cluster analysis and latent class analysis have suggested that Gilles de la Tourette syndrome (GTS) should no longer be considered a unitary condition as in current classification systems. Objective: To identify quantitative components of GTS symptomatology using a large, well characterised cohort of singleton individuals with GTS in order to inform future genetic studies with more homogeneous phenotypes. Methods: Principal component factor analysis with oblique rotation was used to analyse symptom data from a sample of 639 patients recruited at two tertiary referral centres using identical schedules during the period 1980-2008. Results: Three Factors were identified: (1) complex motor tics and echo-paliphenomena; (2) attention deficit and hyperactivity symptoms plus aggressive behaviours; and (3) complex vocal tics and coprophenomena. Obsessive compulsive behaviours loaded significantly on the first two factors. The three factors accounted for 48.5% of the total symptomatic variance. Conclusions: GTS is a phenotypically heterogeneous condition encompassing simple tics, specific complex tics and associated behavioural problems. The results, coupled with previous findings, identified a clinical continuum of complex tics, hyperactivity/impulsivity symptoms and semantically relevant utterances and gestures. A better characterisation of the GTS phenotypes will help to identify susceptibility genes.
Articolo in rivista - Articolo scientifico
adult; aggression; article; attention deficit disorder; complex motor tic; complex vocal tic; coprophenomena; disease duration; disease severity; echo paliphenomena; female; Gilles de la Tourette syndrome; human; major clinical study; male; obsessive compulsive disorder; phenotype; principal component analysis; priority journal; symptomatology; tic
English
2011
82
12
1320
1323
reserved
Cavanna, A., Critchley, H., Orth, M., Stern, J., Young, M., Robertson, M. (2011). Dissecting the Gilles de la Tourette spectrum: A factor analytic study on 639 patients. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 82(12), 1320-1323 [10.1136/jnnp.2010.225029].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/413858
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