Autoimmune liver diseases (AILDs) have an important genetic background. This is supported by different lines of evidence, that is, clustering in families, high concordance rates in monozygotic twins, increased risk of the disease in siblings compared to general population, and association with other autoimmune conditions. In this chapter, we summarize current knowledge regarding each of the three most common AILDs (autoimmune hepatitis, AIH; primary biliary cholangitis, PBC; and primary sclerosing cholangitis, PSC); we then propose a series of possible future lines of investigation to explore the amount of heritability, which is still to be determined.

Gerussi, A., Carbone, M., Asselta, R., Invernizzi, P. (2020). Genetics of Autoimmune Liver Diseases. In E.M. Gershwin, J.M. Vierling, A. Tanaka, M.P. Manns (a cura di), Liver Immunology: Principles and Practice (pp. 69-85). Springer International Publishing [10.1007/978-3-030-51709-0_5].

Genetics of Autoimmune Liver Diseases

Gerussi A.;Carbone M.;Invernizzi P.
2020

Abstract

Autoimmune liver diseases (AILDs) have an important genetic background. This is supported by different lines of evidence, that is, clustering in families, high concordance rates in monozygotic twins, increased risk of the disease in siblings compared to general population, and association with other autoimmune conditions. In this chapter, we summarize current knowledge regarding each of the three most common AILDs (autoimmune hepatitis, AIH; primary biliary cholangitis, PBC; and primary sclerosing cholangitis, PSC); we then propose a series of possible future lines of investigation to explore the amount of heritability, which is still to be determined.
Capitolo o saggio
Autoimmune hepatitis; Autoimmune liver diseases; Primary biliary cholangitis; Primary sclerosing cholangitis;
English
Liver Immunology: Principles and Practice
Gershwin, EM; Vierling, JM; Tanaka, A; Manns, MP
2020
9783030517083
Springer International Publishing
69
85
Gerussi, A., Carbone, M., Asselta, R., Invernizzi, P. (2020). Genetics of Autoimmune Liver Diseases. In E.M. Gershwin, J.M. Vierling, A. Tanaka, M.P. Manns (a cura di), Liver Immunology: Principles and Practice (pp. 69-85). Springer International Publishing [10.1007/978-3-030-51709-0_5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/412216
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