Research trends in Gilles de la Tourette syndrome in 2010‐2015

Background: Gilles de la Tourette syndrome (GTS) is a neurodevelopmental condition characterized by the presence of multiple motor and phonic tics, often associated with co-morbid behavioral problems bearing an impact on patients’ health-related quality of life. The number of scientific publications on GTS has increased considerably in recent years, making it difficult for clinicians and researchers to keep up to date with research developments. Objective: This review aimed to identify and critically evaluate the most important research articles on GTS published over the last five years (2010 to 2015). Methods: A systematic search of original scientific articles in Medline, EMBASE and PsycInfo, complemented by manual screening of journal archives, yielded 490 relevant publications within the reference period. Results: The majority of the identified studies were categorized as belonging to Class III and IV according to the American Academy of Neurology grading system. Following quality appraisal 50 studies were selected for inclusion in the final list of most important articles, and were critically appraised according to methodological design, main focus and wider impact. Conclusion: Analysis of original research publications on GTS shows that our knowledge of the condition has expanded significantly in recent years, yielding new insights on the aetiology, treatment and impact on patients’ health-related quality of life. This body of research has in turn guided the development of new hypotheses and research questions to continue expanding our understanding of GTS and improving care provision.