IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishAIM: To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. METHODS: We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome (MS) was defined according to ATPIII criteria. Iron overload was assessed by liver biopsy. Liver histology was evaluated by Ishak's score and iron accumulation by Deugnier's score; steatosis was diagnosed when present in>=5% of hepatocytes. RESULTS: According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities. Using Receiving Operating Curve analysis, we found that the presence of two components of the MS differentiated two groups with a statistically significant different hepatic iron overload (P < 0.0001). Patients with >= 2 metabolic alterations and steatosis had lower amounts of hepatic iron, lower transferrin saturation and higher sinusoidal iron than patients with < 2 MS components and absence of steatosis. CONCLUSION: In our patients, the presence of >= 2 alterations of the MS and hepatic steatosis were associated with a moderate form of iron overload with a prevalent sinusoidal distribution and a normal transferrin saturation, suggesting the existence of a peculiar pathogenetic mechanism of iron accumulation. These patients may have a typical dysmetabolic iron overload syndrome. By contrast, patients with a transferrin saturation >=60% had more severe iron overload, few or no metabolic abnormalities and a hemochromatosis-like pattern of iron overload
Riva, A., Trombini, P., Mariani, R., Salvioni, A., Coletti, S., Bonfadini, S., et al. (2008). Re-evaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome. WORLD JOURNAL OF GASTROENTEROLOGY, 14(30), 4745-4752 [10.3748/wjg.14.4745].
| Citazione: | Riva, A., Trombini, P., Mariani, R., Salvioni, A., Coletti, S., Bonfadini, S., et al. (2008). Re-evaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome. WORLD JOURNAL OF GASTROENTEROLOGY, 14(30), 4745-4752 [10.3748/wjg.14.4745]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Titolo: | Re-evaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome | |
| Autori: | Riva, A; Trombini, P; Mariani, R; Salvioni, A; Coletti, S; Bonfadini, S; Paolini, V; Pozzi, M; Facchetti, RL; Bovo, G; Piperno, A | |
| Autori: | ||
| Data di pubblicazione: | ago-2008 | |
| Lingua: | English | |
| Rivista: | WORLD JOURNAL OF GASTROENTEROLOGY | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3748/wjg.14.4745 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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