Celiac disease (CD) is a multisystem disease in which different organs may be affected. We investigate whether circulating innate lymphoid cells (ILCs) contribute to the CD peripheral inflammatory status. We find that the CD cytokine profile is characterized by high concentrations of IL-12p40, IL-18, and IFN-γ, paralleled by an expansion of ILC precursors (ILCPs). In the presence of the gliadin peptides p31–43 and pα-9, ILCPs from CD patients increase transglutaminase 2 (TG2) expression, produce IL-18 and IFN-γ, and stimulate CD4+ T lymphocytes. IFN-γ is also produced upon stimulation with IL-12p40 and IL-18 and is inhibited by the addition of vitamin D. Low levels of blood vitamin D correlate with high IFN-γ and ILCP presence and mark the CD population mostly affected by extraintestinal symptoms. Dietary vitamin D supplementation appears to be an interesting therapeutic approach to dampen ILCP-mediated IFN-γ production.

Ercolano, G., Moretti, A., Falquet, M., Wyss, T., Tran, N., Senoner, I., et al. (2022). Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients. CELL REPORTS, 39(11) [10.1016/j.celrep.2022.110956].

Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients

Moretti, Alex
Co-primo
;
2022

Abstract

Celiac disease (CD) is a multisystem disease in which different organs may be affected. We investigate whether circulating innate lymphoid cells (ILCs) contribute to the CD peripheral inflammatory status. We find that the CD cytokine profile is characterized by high concentrations of IL-12p40, IL-18, and IFN-γ, paralleled by an expansion of ILC precursors (ILCPs). In the presence of the gliadin peptides p31–43 and pα-9, ILCPs from CD patients increase transglutaminase 2 (TG2) expression, produce IL-18 and IFN-γ, and stimulate CD4+ T lymphocytes. IFN-γ is also produced upon stimulation with IL-12p40 and IL-18 and is inhibited by the addition of vitamin D. Low levels of blood vitamin D correlate with high IFN-γ and ILCP presence and mark the CD population mostly affected by extraintestinal symptoms. Dietary vitamin D supplementation appears to be an interesting therapeutic approach to dampen ILCP-mediated IFN-γ production.
Articolo in rivista - Articolo scientifico
celiac disease; CP: Immunology; extraintestinal symptoms; gliadin; gluten peptides; IFN-γ; IL-12; IL-18; ILCPs; ILCs; innate lymphoid cells; vitamin D;
English
14-giu-2022
2022
39
11
110956
open
Ercolano, G., Moretti, A., Falquet, M., Wyss, T., Tran, N., Senoner, I., et al. (2022). Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients. CELL REPORTS, 39(11) [10.1016/j.celrep.2022.110956].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/406058
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