It is well known that regulatory T-cells (Tregs) are required to prevent autoimmunity, but they may also have some less-well understood immune-stimulatory effects. In particular, in CD8(+) T-cell responses Tregs select high-affinity clones upon priming and promote memory by inhibiting inflammation-dependent generation of short-lived effector cells. In the current issue of the European Journal of Immunology [Eur. J. Immunol. 2023. 53: XXXX-XXXX], Madi et al. report the surprising finding that human and murine FOXP3(+) Tregs are a physiologically relevant source of IL-15, a homeostatic cytokine that promotes antigen-independent maintenance of CD8(+) memory T-cells. In mice that lack IL-15 selectively in FOXP3(+)Tregs the authors show that the composition of the CD8(+) T-cell memory pool is altered in the absence of Treg-derived IL-15, since a subset of terminally effector memory cells is drastically reduced. Otherwise Treg-derived IL-15 is dispensable for antiviral immune responses and the generation of anti-viral CD8(+) memory T-cells. These findings add to our understanding of the multifaceted role of Tregs in immune responses, and how IL-15 derived from different cellular sources maintains anti-viral T-cell memory.

Geginat, J., Granucci, F. (2023). Regulatory T-cell-derived interleukin-15 shapes cytotoxic T cell memory. EUROPEAN JOURNAL OF IMMUNOLOGY, 53(1 (January 2023)) [10.1002/eji.202250238].

Regulatory T-cell-derived interleukin-15 shapes cytotoxic T cell memory

Granucci F.
Ultimo
2023

Abstract

It is well known that regulatory T-cells (Tregs) are required to prevent autoimmunity, but they may also have some less-well understood immune-stimulatory effects. In particular, in CD8(+) T-cell responses Tregs select high-affinity clones upon priming and promote memory by inhibiting inflammation-dependent generation of short-lived effector cells. In the current issue of the European Journal of Immunology [Eur. J. Immunol. 2023. 53: XXXX-XXXX], Madi et al. report the surprising finding that human and murine FOXP3(+) Tregs are a physiologically relevant source of IL-15, a homeostatic cytokine that promotes antigen-independent maintenance of CD8(+) memory T-cells. In mice that lack IL-15 selectively in FOXP3(+)Tregs the authors show that the composition of the CD8(+) T-cell memory pool is altered in the absence of Treg-derived IL-15, since a subset of terminally effector memory cells is drastically reduced. Otherwise Treg-derived IL-15 is dispensable for antiviral immune responses and the generation of anti-viral CD8(+) memory T-cells. These findings add to our understanding of the multifaceted role of Tregs in immune responses, and how IL-15 derived from different cellular sources maintains anti-viral T-cell memory.
Articolo in rivista - Articolo scientifico
regulatory T cells ⋅ IL-15 ⋅ FOXP3 ⋅ CD8+ memory T cells;
English
18-nov-2022
2023
53
1 (January 2023)
2250238
reserved
Geginat, J., Granucci, F. (2023). Regulatory T-cell-derived interleukin-15 shapes cytotoxic T cell memory. EUROPEAN JOURNAL OF IMMUNOLOGY, 53(1 (January 2023)) [10.1002/eji.202250238].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/405040
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