Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially those displaying rapid-cycling and mixed states. This paper reviews the multiple mechanisms of action and the tolerability profile of TPM in the light of its therapeutic potential in affective disorders. Studies of TPM in bipolar disorder are evaluated, and the efficacy and tolerability issues as a mood stabilizing agent are discussed.

Mula, M., Cavanna, A., Monaco, F. (2006). Psychopharmacology of topiramate: From epilepsy to bipolar disorder. NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2(4), 475-488 [10.2147/nedt.2006.2.4.587].

Psychopharmacology of topiramate: From epilepsy to bipolar disorder

Cavanna A
;
2006

Abstract

Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially those displaying rapid-cycling and mixed states. This paper reviews the multiple mechanisms of action and the tolerability profile of TPM in the light of its therapeutic potential in affective disorders. Studies of TPM in bipolar disorder are evaluated, and the efficacy and tolerability issues as a mood stabilizing agent are discussed.
Articolo in rivista - Articolo scientifico
Psychopharmacology, topiramate, epilepsy, bipolar disorder
English
2006
2
4
475
488
reserved
Mula, M., Cavanna, A., Monaco, F. (2006). Psychopharmacology of topiramate: From epilepsy to bipolar disorder. NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2(4), 475-488 [10.2147/nedt.2006.2.4.587].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/403556
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