The atypical chemokine receptor D6 is a decoy and scavenger receptor for most inflammatory CC chemokines and prevents the development of exacerbated inflammatory reactions. Here we report that mice lacking D6 expression in the nonhematopoietic compartment have a selective increase in the number of Ly6Chigh monocytes in the circulation and in secondary lymphoid tissues. Under inflammatory conditions, Ly6Chigh monocytes accumulate in increased number in secondary lymphoid organs of D6-/- mice in a CCR2-dependent manner. Ly6Chigh monocytes derived from D6-/- mice have enhanced immunosuppressive activity, inhibit the development of adaptive immune responses, and partially protect mice from the development of GVHD. Thus, control of CCR2 ligands by D6 regulates the traffic of Ly6Chigh monocytes and controls their immunosuppressive potential.

Savino, B., Castor, M., Caronni, N., Sarukhan, A., Anselmo, A., Buracchi, C., et al. (2012). Control of murine Ly6Chigh monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6. BLOOD, 119(22), 5250-5260 [10.1182/blood-2011-10-388082].

Control of murine Ly6Chigh monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6

Buracchi C.;
2012

Abstract

The atypical chemokine receptor D6 is a decoy and scavenger receptor for most inflammatory CC chemokines and prevents the development of exacerbated inflammatory reactions. Here we report that mice lacking D6 expression in the nonhematopoietic compartment have a selective increase in the number of Ly6Chigh monocytes in the circulation and in secondary lymphoid tissues. Under inflammatory conditions, Ly6Chigh monocytes accumulate in increased number in secondary lymphoid organs of D6-/- mice in a CCR2-dependent manner. Ly6Chigh monocytes derived from D6-/- mice have enhanced immunosuppressive activity, inhibit the development of adaptive immune responses, and partially protect mice from the development of GVHD. Thus, control of CCR2 ligands by D6 regulates the traffic of Ly6Chigh monocytes and controls their immunosuppressive potential.
Articolo in rivista - Articolo scientifico
atypical, chemokine receptors, graft-versus-host disease, immunosuppressive agents, mice, monocytes
English
2012
119
22
5250
5260
none
Savino, B., Castor, M., Caronni, N., Sarukhan, A., Anselmo, A., Buracchi, C., et al. (2012). Control of murine Ly6Chigh monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6. BLOOD, 119(22), 5250-5260 [10.1182/blood-2011-10-388082].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/403337
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