The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this issue, we performed a novel case-control study and a meta-analysis of published association studies between PRNP and AD. Our findings argue against PRNP as a susceptibility gene for developing AD in the Italian population but support the hypothesis that the V allele influences cognitive performances. The meta-analysis, revealed that Caucasian subjects homozygous at codon 129 had a 1.3-fold increased risk [95% CI: 1.0-1.6, p = 0.05] of developing AD compared to heterozygous individuals. We also observed that MM genotype and M allele represent a risk factor for AD, independently from the ethnic background, providing a significant but modest association between this polymorphism and AD.
Del Bo, R., Scarlato, M., Ghezzi, S., Martinelli-Boneschi, F., Fenoglio, C., Galimberti, G., et al. (2006). Is M129V of PRNP gene associated with Alzheimer's disease? A case control study and a meta-analysis. NEUROBIOLOGY OF AGING, 27(5), 770-775.
Citazione: | Del Bo, R., Scarlato, M., Ghezzi, S., Martinelli-Boneschi, F., Fenoglio, C., Galimberti, G., et al. (2006). Is M129V of PRNP gene associated with Alzheimer's disease? A case control study and a meta-analysis. NEUROBIOLOGY OF AGING, 27(5), 770-775. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Titolo: | Is M129V of PRNP gene associated with Alzheimer's disease? A case control study and a meta-analysis |
Autori: | Del Bo, R; Scarlato, M; Ghezzi, S; Martinelli-Boneschi, F; Fenoglio, C; Galimberti, G; Galbiati, S; Virgilio, R; Galimberti, D; Ferrarese, C; Scarpini, E; Bresolin, N; Comi, GP; |
Autori: | |
Data di pubblicazione: | 2006 |
Lingua: | English |
Rivista: | NEUROBIOLOGY OF AGING |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.neurobiolaging.2005.05.025 |
Appare nelle tipologie: | 01 - Articolo su rivista |