Expectations about future events are known to trigger neural mechanisms that affect both perception and action. Here we report that different and opposite expectations of bad and good motor performance modulate the therapeutic effects of subthalamic nucleus stimulation in Parkinsonian patients who had undergone chronic implantation of electrodes for deep brain stimulation. By analyzing the effects of subthalamic stimulation on the velocity of movement of the right hand, we found hand movement to be faster when the patients expected a good motor performance. The expectation of good performance was induced through a placebo-like procedure, thus indicating that placebo-induced expectations have influence on the treatment outcome. All these effects occurred within minutes, suggesting that expectations induce neural changes very quickly.

Pollo, A., Torre, E., Lopiano, L., Rizzone, M., Lanotte, M., Cavanna, A., et al. (2002). Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients. NEUROREPORT, 13(11), 1383-1386 [10.1097/00001756-200208070-00006].

Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients

Cavanna A;
2002

Abstract

Expectations about future events are known to trigger neural mechanisms that affect both perception and action. Here we report that different and opposite expectations of bad and good motor performance modulate the therapeutic effects of subthalamic nucleus stimulation in Parkinsonian patients who had undergone chronic implantation of electrodes for deep brain stimulation. By analyzing the effects of subthalamic stimulation on the velocity of movement of the right hand, we found hand movement to be faster when the patients expected a good motor performance. The expectation of good performance was induced through a placebo-like procedure, thus indicating that placebo-induced expectations have influence on the treatment outcome. All these effects occurred within minutes, suggesting that expectations induce neural changes very quickly.
Articolo in rivista - Articolo scientifico
Deep brain stimulation; Expectation; Motor performance; Parkinson's disease; Placebo; Subthalamic nucleus;
English
2002
13
11
1383
1386
reserved
Pollo, A., Torre, E., Lopiano, L., Rizzone, M., Lanotte, M., Cavanna, A., et al. (2002). Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients. NEUROREPORT, 13(11), 1383-1386 [10.1097/00001756-200208070-00006].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/402197
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