Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications.

Arpino, G., Generali, D., Sapino, A., Del Matro, L., Frassoldati, A., de Laurentis, M., et al. (2013). Gene expression profiling in breast cancer: a clinical perspective. THE BREAST, 22(2), 109-120 [10.1016/j.breast.2013.01.016].

Gene expression profiling in breast cancer: a clinical perspective

Cazzaniga, M;
2013

Abstract

Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications.
Articolo in rivista - Review Essay
Breast cancer; Gene arrays; Gene profiles; Prognostic factors;
English
2013
22
2
109
120
open
Arpino, G., Generali, D., Sapino, A., Del Matro, L., Frassoldati, A., de Laurentis, M., et al. (2013). Gene expression profiling in breast cancer: a clinical perspective. THE BREAST, 22(2), 109-120 [10.1016/j.breast.2013.01.016].
File in questo prodotto:
File Dimensione Formato  
Arpino-2013-Breast-VoR.pdf

accesso aperto

Descrizione: Review
Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Licenza: Creative Commons
Dimensione 496.66 kB
Formato Adobe PDF
496.66 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/402137
Citazioni
  • Scopus 68
  • ???jsp.display-item.citation.isi??? 58
Social impact