Late fetal liver hematopoiesis was thought to primarily rely on hematopoietic stem cells (HSCs). Using new genetic-tracing tools, a study shows that EVI1-positive HSCs mainly undergo expansion in the fetal liver, while differentiated blood cell production depends on HSC-independent intermediate hematopoietic progenitors.
Azzoni, E., Fantin, A. (2022). Fetal liver hematopoiesis revisited: a precast hierarchy. NATURE CARDIOVASCULAR RESEARCH, 1(10), 872-873 [10.1038/s44161-022-00142-5].
Fetal liver hematopoiesis revisited: a precast hierarchy
Azzoni, Emanuele
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2022
Abstract
Late fetal liver hematopoiesis was thought to primarily rely on hematopoietic stem cells (HSCs). Using new genetic-tracing tools, a study shows that EVI1-positive HSCs mainly undergo expansion in the fetal liver, while differentiated blood cell production depends on HSC-independent intermediate hematopoietic progenitors.
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