Intraplacental choriocarcinoma (IC) is a rare type of gestational choriocarcinoma (GC) occurring within the placenta, and only a small number of cases have been reported so far. Intraplacental choriocarcinoma is usually asymptomatic or may present with aspecific symptoms, including unexplained vaginal bleeding during pregnancy. Early diagnosis and treatment are pivotal for ensuring optimal outcomes. However, intraplacental choriocarcinoma is rarely suspected due to limited knowledge and awareness of the condition. Here, we report the case of a 34-year-old woman diagnosed with intraplacental choriocarcinoma by placental histological examination performed after delivery due to unexplained vaginal bleeding at 29 gestational weeks, requiring hospital admission. Two lines of chemotherapy and surgery were necessary to achieve complete remission. Since unexplained vaginal bleeding during pregnancy can be a clinical manifestation of intraplacental choriocarcinoma, we propose to consider placental histological examination in all pregnancies with this complication.

Sala, A., Ornaghi, S., Delle Marchette, M., Bonazzi, C., Gorla, S., Moltrasio, F., et al. (2022). Gestational Intraplacental Choriocarcinoma in a Term Pregnancy: A Case Report. CUREUS, 14(11) [10.7759/cureus.31243].

Gestational Intraplacental Choriocarcinoma in a Term Pregnancy: A Case Report

Sala, Andrea;Ornaghi, Sara;Delle Marchette, Martina;Fruscio, Robert;Vergani, Patrizia;Landoni, Fabio
2022

Abstract

Intraplacental choriocarcinoma (IC) is a rare type of gestational choriocarcinoma (GC) occurring within the placenta, and only a small number of cases have been reported so far. Intraplacental choriocarcinoma is usually asymptomatic or may present with aspecific symptoms, including unexplained vaginal bleeding during pregnancy. Early diagnosis and treatment are pivotal for ensuring optimal outcomes. However, intraplacental choriocarcinoma is rarely suspected due to limited knowledge and awareness of the condition. Here, we report the case of a 34-year-old woman diagnosed with intraplacental choriocarcinoma by placental histological examination performed after delivery due to unexplained vaginal bleeding at 29 gestational weeks, requiring hospital admission. Two lines of chemotherapy and surgery were necessary to achieve complete remission. Since unexplained vaginal bleeding during pregnancy can be a clinical manifestation of intraplacental choriocarcinoma, we propose to consider placental histological examination in all pregnancies with this complication.
Articolo in rivista - Articolo scientifico
choriocarcinoma; gestational trophoblastic disease; oncology; placenta; pregnancy; trophoblasts
English
8-nov-2022
2022
14
11
e31243
none
Sala, A., Ornaghi, S., Delle Marchette, M., Bonazzi, C., Gorla, S., Moltrasio, F., et al. (2022). Gestational Intraplacental Choriocarcinoma in a Term Pregnancy: A Case Report. CUREUS, 14(11) [10.7759/cureus.31243].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/400003
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