Background: This study aimed at testing the ability of the frontal assessment battery (FAB) to differentiate between patients with mild cognitive impairment (MCI) and dementia due to Alzheimer’s disease (AD), as well as comparing its discriminative power to that of the Mini-Mental State Examination (MMSE). Methods: The present retrospective cohort included N = 107 Aβ-positive patients diagnosed with either MCI due to AD (N = 40) or probable AD dementia (ADD; N = 67). A two-step multiple logistic regression (MLR) was run to predict an MCI vs. ADD diagnosis based on FAB scores. Within the baseline step, demographics, disease duration, MMSE scores, and information on cognitive phenotypes were entered, with the FAB being added within the second step. Receiver-operating characteristics analyses were also run to derive intrinsic and post-test diagnostics. Results: Within the baseline MLR step, only lower MMSE scores predicted the occurrence of ADD; by adding the FAB, which likewise was able to discriminate between MCI and ADD (p = 0.016), a significant increase in model fit was detected (p = 0.007). The diagnostic efficiency of the FAB (AUC = 0.85) was comparable (p = 0.583) to that of the MMSE (AUC = 0.82), also yielding good intrinsic and post-test diagnostics, which were comparable to those of the MMSE. Discussion: The FAB is a diagnostically sound screener to discriminate between MCI and ADD, independently of patients’ overall cognitive profile. In doing so, the FAB is comparable to the MMSE, and the complementation of the latter with the former is advisable in order to increase the accuracy in differentiating between MCI and ADD within screening sessions.

Aiello, E., Verde, F., Milone, I., Giacopuzzi Grigoli, E., Dubini, A., Carelli, L., et al. (2022). The Frontal Assessment Battery ({FAB}) effectively discriminates between {MCI} and dementia within the clinical spectrum of neurochemically confirmed Alzheimer's disease. FRONTIERS IN PSYCHOLOGY, 13 [10.3389/fpsyg.2022.1054321].

The Frontal Assessment Battery ({FAB}) effectively discriminates between {MCI} and dementia within the clinical spectrum of neurochemically confirmed Alzheimer's disease

Edoardo Nicolò Aiello;
2022

Abstract

Background: This study aimed at testing the ability of the frontal assessment battery (FAB) to differentiate between patients with mild cognitive impairment (MCI) and dementia due to Alzheimer’s disease (AD), as well as comparing its discriminative power to that of the Mini-Mental State Examination (MMSE). Methods: The present retrospective cohort included N = 107 Aβ-positive patients diagnosed with either MCI due to AD (N = 40) or probable AD dementia (ADD; N = 67). A two-step multiple logistic regression (MLR) was run to predict an MCI vs. ADD diagnosis based on FAB scores. Within the baseline step, demographics, disease duration, MMSE scores, and information on cognitive phenotypes were entered, with the FAB being added within the second step. Receiver-operating characteristics analyses were also run to derive intrinsic and post-test diagnostics. Results: Within the baseline MLR step, only lower MMSE scores predicted the occurrence of ADD; by adding the FAB, which likewise was able to discriminate between MCI and ADD (p = 0.016), a significant increase in model fit was detected (p = 0.007). The diagnostic efficiency of the FAB (AUC = 0.85) was comparable (p = 0.583) to that of the MMSE (AUC = 0.82), also yielding good intrinsic and post-test diagnostics, which were comparable to those of the MMSE. Discussion: The FAB is a diagnostically sound screener to discriminate between MCI and ADD, independently of patients’ overall cognitive profile. In doing so, the FAB is comparable to the MMSE, and the complementation of the latter with the former is advisable in order to increase the accuracy in differentiating between MCI and ADD within screening sessions.
Articolo in rivista - Articolo scientifico
Alzheimer’s disease; cerebrospinal fluid; executive functioning; frontal assessment battery; mild cognitive impairment;
English
2022
13
1054321
none
Aiello, E., Verde, F., Milone, I., Giacopuzzi Grigoli, E., Dubini, A., Carelli, L., et al. (2022). The Frontal Assessment Battery ({FAB}) effectively discriminates between {MCI} and dementia within the clinical spectrum of neurochemically confirmed Alzheimer's disease. FRONTIERS IN PSYCHOLOGY, 13 [10.3389/fpsyg.2022.1054321].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/399813
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