Standard enteral preparations have been modified by adding specific nutrients: arginine, omega-3 fatty acids, and nucleotides.These up-regulate host immune response, to control inflammatory response, and to improve nitrogen balance and protein synthesis after injury.The majority of randomized trials focused on clinical outcome have been carried out in GI cancer elective surgical patients.When immunonutrition was limited to postoperative period the results were conflicting.Better results on outcome were obtained when the provision of the immunoenhancing diet was anticipated before surgery.This allowed to significantly reduce postoperative infection rate either in malnourished or in well nourished patients.Cost–benefit analyses showed that immunonutrition resulted in a positive cost-effectiveness ratio compared to conventional treatment. Standard enteral preparations have been modified by adding specific nutrients: arginine, omega-3 fatty acids, and nucleotides. These up-regulate host immune response, to control inflammatory response, and to improve nitrogen balance and protein synthesis after injury. The majority of randomized trials focused on clinical outcome have been carried out in GI cancer elective surgical patients. When immunonutrition was limited to postoperative period the results were conflicting. Better results on outcome were obtained when the provision of the immunoenhancing diet was anticipated before surgery. This allowed to significantly reduce postoperative infection rate either in malnourished or in well nourished patients. Cost–benefit analyses showed that immunonutrition resulted in a positive cost-effectiveness ratio compared to conventional treatment.
Braga, M., Rocchetti, S. (2011). Preoperative Immunonutrition: Cost–Benefit Analysis. In J.K. Gerald, R.R. Watson, V.R. Preedy (a cura di), Nutrients, Dietary Supplements, and Nutriceuticals. Cost Analysis Versus Clinical Benefits (pp. 315-320). Humana Press [10.1007/978-1-60761-308-4_20].
Preoperative Immunonutrition: Cost–Benefit Analysis
Braga, M;
2011
Abstract
Standard enteral preparations have been modified by adding specific nutrients: arginine, omega-3 fatty acids, and nucleotides.These up-regulate host immune response, to control inflammatory response, and to improve nitrogen balance and protein synthesis after injury.The majority of randomized trials focused on clinical outcome have been carried out in GI cancer elective surgical patients.When immunonutrition was limited to postoperative period the results were conflicting.Better results on outcome were obtained when the provision of the immunoenhancing diet was anticipated before surgery.This allowed to significantly reduce postoperative infection rate either in malnourished or in well nourished patients.Cost–benefit analyses showed that immunonutrition resulted in a positive cost-effectiveness ratio compared to conventional treatment. Standard enteral preparations have been modified by adding specific nutrients: arginine, omega-3 fatty acids, and nucleotides. These up-regulate host immune response, to control inflammatory response, and to improve nitrogen balance and protein synthesis after injury. The majority of randomized trials focused on clinical outcome have been carried out in GI cancer elective surgical patients. When immunonutrition was limited to postoperative period the results were conflicting. Better results on outcome were obtained when the provision of the immunoenhancing diet was anticipated before surgery. This allowed to significantly reduce postoperative infection rate either in malnourished or in well nourished patients. Cost–benefit analyses showed that immunonutrition resulted in a positive cost-effectiveness ratio compared to conventional treatment.
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