Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.

De Monte, L., Sanvito, F., Olivieri, S., Vigano, F., Doglioni, C., Frasson, M., et al. (2008). Serological immunoreactivity against colon cancer proteorne varies upon disease progression. JOURNAL OF PROTEOME RESEARCH, 7(2), 504-514 [10.1021/pr070360m].

Serological immunoreactivity against colon cancer proteorne varies upon disease progression

Braga M;
2008

Abstract

Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.
Articolo in rivista - Articolo scientifico
2D electrophoresis; Colorectal carcinoma; Proteomics; Tumor-associated antigens;
English
2008
7
2
504
514
none
De Monte, L., Sanvito, F., Olivieri, S., Vigano, F., Doglioni, C., Frasson, M., et al. (2008). Serological immunoreactivity against colon cancer proteorne varies upon disease progression. JOURNAL OF PROTEOME RESEARCH, 7(2), 504-514 [10.1021/pr070360m].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/399138
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