Various neurological complications, affecting both the central and peripheral nervous system, can frequently be experienced by cancer survivors after exposure to conventional chemotherapy, but also to modern immunotherapy. In this review, we provide an overview of the most well-known adverse events related to chemotherapy, with a focus on chemotherapy induced peripheral neurotoxicity, but we also address some emerging novel clinical entities related to cancer treatment, including chemotherapy-related cognitive impairment and immune-mediated adverse events. Unfortunately, efficacious curative or preventive treatment for all these neurological complications is still lacking. We provide a description of the possible mechanisms involved to drive future drug discovery in this field, both for symptomatic treatment and neuroprotection.

Alberti, P., Salvalaggio, A., Argyriou, A., Bruna, J., Visentin, A., Cavaletti, G., et al. (2022). Neurological Complications of Conventional and Novel Anticancer Treatments. CANCERS, 14(24) [10.3390/cancers14246088].

Neurological Complications of Conventional and Novel Anticancer Treatments

Alberti, Paola
Primo
;
Cavaletti, Guido
Penultimo
;
2022

Abstract

Various neurological complications, affecting both the central and peripheral nervous system, can frequently be experienced by cancer survivors after exposure to conventional chemotherapy, but also to modern immunotherapy. In this review, we provide an overview of the most well-known adverse events related to chemotherapy, with a focus on chemotherapy induced peripheral neurotoxicity, but we also address some emerging novel clinical entities related to cancer treatment, including chemotherapy-related cognitive impairment and immune-mediated adverse events. Unfortunately, efficacious curative or preventive treatment for all these neurological complications is still lacking. We provide a description of the possible mechanisms involved to drive future drug discovery in this field, both for symptomatic treatment and neuroprotection.
Articolo in rivista - Review Essay
chemobrain; chemofog; chemotherapy-induced peripheral neuropathy; chemotherapy-induced peripheral neurotoxicity; chemotherapy-related cognitive impairment; immune-checkpoint inhibitors neurotoxicity;
English
10-dic-2022
2022
14
24
6088
open
Alberti, P., Salvalaggio, A., Argyriou, A., Bruna, J., Visentin, A., Cavaletti, G., et al. (2022). Neurological Complications of Conventional and Novel Anticancer Treatments. CANCERS, 14(24) [10.3390/cancers14246088].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/399035
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