The role of T-type calcium channels is well established in excitable cells, where they preside over action potential generation, automaticity, and firing. They also contribute to intracellular calcium signaling, cell cycle progression, and cell fate; and, in this sense, they emerge as key regulators also in non-excitable cells. In particular, their expression may be considered a prognostic factor in cancer. Almost all cancer cells express T-type calcium channels to the point that it has been considered a pharmacological target; but, as the drugs used to reduce their expression are not completely selective, several complications develop, especially within the heart. T-type calcium channels are also involved in a specific side effect of several anticancer agents, that act on microtubule transport, increase the expression of the channel, and, thus, the excitability of sensory neurons, and make the patient more sensitive to pain. This review puts into context the relevance of T-type calcium channels in cancer and in chemotherapy side effects, considering also the cardiotoxicity induced by new classes of antineoplastic molecules.

Melgari, D., Frosio, A., Calamaio, S., Marzi, G., Pappone, C., Rivolta, I. (2022). T-Type Calcium Channels: A Mixed Blessing. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(17) [10.3390/ijms23179894].

T-Type Calcium Channels: A Mixed Blessing

Melgari, Dario;Calamaio, Serena;Rivolta, Ilaria
2022

Abstract

The role of T-type calcium channels is well established in excitable cells, where they preside over action potential generation, automaticity, and firing. They also contribute to intracellular calcium signaling, cell cycle progression, and cell fate; and, in this sense, they emerge as key regulators also in non-excitable cells. In particular, their expression may be considered a prognostic factor in cancer. Almost all cancer cells express T-type calcium channels to the point that it has been considered a pharmacological target; but, as the drugs used to reduce their expression are not completely selective, several complications develop, especially within the heart. T-type calcium channels are also involved in a specific side effect of several anticancer agents, that act on microtubule transport, increase the expression of the channel, and, thus, the excitability of sensory neurons, and make the patient more sensitive to pain. This review puts into context the relevance of T-type calcium channels in cancer and in chemotherapy side effects, considering also the cardiotoxicity induced by new classes of antineoplastic molecules.
Articolo in rivista - Review Essay
bortezomib; cancer therapy; cardiotoxicity; carfilzomib; mibefradil; peripheral neuropathy; T-type Ca2+ channel; T-type calcium channel blocker;
English
Melgari, D., Frosio, A., Calamaio, S., Marzi, G., Pappone, C., Rivolta, I. (2022). T-Type Calcium Channels: A Mixed Blessing. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(17) [10.3390/ijms23179894].
Melgari, D; Frosio, A; Calamaio, S; Marzi, G; Pappone, C; Rivolta, I
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/397490
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