Aortic dissection is a complex, intramural, and dynamic condition involving multiple mechanisms, hence, difficult to observe. In the present study, a controlled in vitro aortic dissection was performed using tension-inflation tests on notched rabbit aortic segments. The mechanical test was combined with conventional (cCT) and synchrotron (sCT) computed tomography for in situ imaging of the macro- and micro-structural morphological changes of the aortic wall during dissection. We demonstrate that the morphology of the notch and the aorta can be quantified in situ at different steps of the aortic dissection, and that the notch geometry correlates with the critical pressure. The phenomena prior to propagation of the notch are also described, for instance the presence of a bulge at the tip of the notch is identified, deforming the remaining wall. Finally, our method allows us to visualize for the first time the propagation of an aortic dissection in real-time with a resolution that has never previously been reached. Statement of significance: With the present study, we investigated the factors leading to the propagation of aortic dissection by reproducing this mechanical process in notched rabbit aortas. Synchrotron CT provided the first visualisation in real-time of an aortic dissection propagation with a resolution that has never previously been reached. The morphology of the intimal tear and aorta was quantified at different steps of the aortic dissection, demonstrating that the early notch geometry correlates with the critical pressure. This quantification is crucial for the development of better criteria identifying patients at risk. Phenomena prior to tear propagation were also described, such as the presence of a bulge at the tip of the notch, deforming the remaining wall.

Brunet, J., Pierrat, B., Adrien, J., Maire, E., Lane, B., Curt, N., et al. (2023). In situ visualization of aortic dissection propagation in notched rabbit aorta using synchrotron X-ray tomography. ACTA BIOMATERIALIA, 155(1 January 2023), 449-460 [10.1016/j.actbio.2022.10.060].

In situ visualization of aortic dissection propagation in notched rabbit aorta using synchrotron X-ray tomography

Bravin A.;
2023

Abstract

Aortic dissection is a complex, intramural, and dynamic condition involving multiple mechanisms, hence, difficult to observe. In the present study, a controlled in vitro aortic dissection was performed using tension-inflation tests on notched rabbit aortic segments. The mechanical test was combined with conventional (cCT) and synchrotron (sCT) computed tomography for in situ imaging of the macro- and micro-structural morphological changes of the aortic wall during dissection. We demonstrate that the morphology of the notch and the aorta can be quantified in situ at different steps of the aortic dissection, and that the notch geometry correlates with the critical pressure. The phenomena prior to propagation of the notch are also described, for instance the presence of a bulge at the tip of the notch is identified, deforming the remaining wall. Finally, our method allows us to visualize for the first time the propagation of an aortic dissection in real-time with a resolution that has never previously been reached. Statement of significance: With the present study, we investigated the factors leading to the propagation of aortic dissection by reproducing this mechanical process in notched rabbit aortas. Synchrotron CT provided the first visualisation in real-time of an aortic dissection propagation with a resolution that has never previously been reached. The morphology of the intimal tear and aorta was quantified at different steps of the aortic dissection, demonstrating that the early notch geometry correlates with the critical pressure. This quantification is crucial for the development of better criteria identifying patients at risk. Phenomena prior to tear propagation were also described, such as the presence of a bulge at the tip of the notch, deforming the remaining wall.
Articolo in rivista - Articolo scientifico
Aortic dissection; In situ testing; Synchrotron X-ray tomography; Tear propagation; Tension-inflation test;
English
4-nov-2022
2023
155
1 January 2023
449
460
embargoed_20241104
Brunet, J., Pierrat, B., Adrien, J., Maire, E., Lane, B., Curt, N., et al. (2023). In situ visualization of aortic dissection propagation in notched rabbit aorta using synchrotron X-ray tomography. ACTA BIOMATERIALIA, 155(1 January 2023), 449-460 [10.1016/j.actbio.2022.10.060].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/396850
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