Chronic inflammation is the hallmark of fibrotic disorders and is characterized by the activation of immune cells in the damaged tissues. Macrophages have emerged as central players in the fibrotic process since they initiate, sustain and amplify the inflammatory reaction. As regards the liver, distinct populations of phagocytic cells, like Kupffer cells and monocyte‐derived macrophages, are indisputably key cells implicated in the pathogenesis of several chronic liver diseases. In this review, we summarize the current knowledge on the origin, role and functions of macrophages in fibrotic conditions, with a specific focus on liver fibrosis; then, we discuss some innovative therapeutic strategies targeting macrophages in fibrotic liver diseases.

Binatti, E., Gerussi, A., Barisani, D., Invernizzi, P. (2022). The Role of Macrophages in Liver Fibrosis: New Therapeutic Opportunities. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(12) [10.3390/ijms23126649].

The Role of Macrophages in Liver Fibrosis: New Therapeutic Opportunities

Binatti E.;Gerussi A.;Barisani D.;Invernizzi P.
2022

Abstract

Chronic inflammation is the hallmark of fibrotic disorders and is characterized by the activation of immune cells in the damaged tissues. Macrophages have emerged as central players in the fibrotic process since they initiate, sustain and amplify the inflammatory reaction. As regards the liver, distinct populations of phagocytic cells, like Kupffer cells and monocyte‐derived macrophages, are indisputably key cells implicated in the pathogenesis of several chronic liver diseases. In this review, we summarize the current knowledge on the origin, role and functions of macrophages in fibrotic conditions, with a specific focus on liver fibrosis; then, we discuss some innovative therapeutic strategies targeting macrophages in fibrotic liver diseases.
Articolo in rivista - Review Essay
drug delivery; fibrosis; inflammation; Kupffer cells; liver fibrosis; macrophages; targeted therapies;
English
14-giu-2022
2022
23
12
6649
open
Binatti, E., Gerussi, A., Barisani, D., Invernizzi, P. (2022). The Role of Macrophages in Liver Fibrosis: New Therapeutic Opportunities. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(12) [10.3390/ijms23126649].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/395912
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