Isoflurane is a volatile anesthetic that has a vasodilating effect on cerebral vessels producing a cerebral blood flow increase. Furthermore, it has been shown in animal studies that isoflurane, when used as a preconditioning agent, has neuroprotective properties, inducing tolerance to ischemia. However, it is not routinely used in neurointensive care because of the potential increase in intracranial pressure caused by the rise in cerebral blood flow. Nevertheless, subarachnoid hemorrhage patients who are at risk for vasospasm may benefit from an increase in cerebral blood flow. We measured regional cerebral blood flow during intravenous sedation with propofol and during sedation with isoflurane in patients with severe subarachnoid hemorrhage not having intracranial hypertension
Villa, F., Iacca, C., Molinari, A., Giussani, C., Aletti, G., Pesenti, A., et al. (2012). Inhalation versus endovenous sedation in subarachnoid hemorrhage patients: effects on regional cerebral blood flow. CRITICAL CARE MEDICINE, 40(10), 2797-2804 [10.1097/CCM.0b013e31825b8bc6].
Inhalation versus endovenous sedation in subarachnoid hemorrhage patients: effects on regional cerebral blood flow
GIUSSANI, CARLO GIORGIO;CITERIO, GIUSEPPEUltimo
2012
Abstract
Isoflurane is a volatile anesthetic that has a vasodilating effect on cerebral vessels producing a cerebral blood flow increase. Furthermore, it has been shown in animal studies that isoflurane, when used as a preconditioning agent, has neuroprotective properties, inducing tolerance to ischemia. However, it is not routinely used in neurointensive care because of the potential increase in intracranial pressure caused by the rise in cerebral blood flow. Nevertheless, subarachnoid hemorrhage patients who are at risk for vasospasm may benefit from an increase in cerebral blood flow. We measured regional cerebral blood flow during intravenous sedation with propofol and during sedation with isoflurane in patients with severe subarachnoid hemorrhage not having intracranial hypertensionFile | Dimensione | Formato | |
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