AN IN VITRO STUDY ABOUT THE ALLOGRO (R) EFFECT ON ADIPOSE DERIVED STEM CELLS AND HUMAN OSTEOBLAST: A COMPARATIVE STUDY

The reconstruction of bony defects is still a big concern for the oral surgeon. Autogenous bone is a good candidate for reconstruction, but it requires a second surgical procedure at a different site, involving additional time, extra cost, and potential for problems such as infection. At present, many bone-grafting products have been introduced. Allogro (R) (Ceramed, Lakewood, CO) is a demineralized freeze-dried bone allograft, useful as scaffold to fill bone defects and to restore bone loss in orthopedic and maxillofacial surgery. The present study shows that Allogro (R) leads to osteoblast phenotype expression and extracellular matrix deposition in ADSCs by the activation of osteoblast related genes SP7, COL1A1 and SPP1 and the under-expression of ENG.