We propose a response-adaptive design, described in terms of urn model, whose allocation proportion converges to prespecified values. The main asymptotic results concerning the urn designs are presented and discussed. We adopt the urn model to implement the random allocation procedure of an experiment that aims at testing the mean effect of two treatments. We conduct a statistical analysis on the inferential performance of different tests and we show that, given a non adaptive test T0, the response adaptive model constructs a test T that is better than T0, in terms of (a) higher power and (b) fewer subjects assigned to the inferior treatment. A retrospective real case study is presented.

Ghiglietti, A., Paganoni, A. (2014). Statistical properties of urn designs in clinical trials. In 47th Scientific Meeting of the Italian Statistical Society Proceedings (pp.1-8). Cagliari : CUEC.

Statistical properties of urn designs in clinical trials

Ghiglietti, A;
2014

Abstract

We propose a response-adaptive design, described in terms of urn model, whose allocation proportion converges to prespecified values. The main asymptotic results concerning the urn designs are presented and discussed. We adopt the urn model to implement the random allocation procedure of an experiment that aims at testing the mean effect of two treatments. We conduct a statistical analysis on the inferential performance of different tests and we show that, given a non adaptive test T0, the response adaptive model constructs a test T that is better than T0, in terms of (a) higher power and (b) fewer subjects assigned to the inferior treatment. A retrospective real case study is presented.
No
paper
Scientifica
Clinical trials; Randomly Reinforced Urns; Tests based on adaptive procedures
English
SIS 2014 - Scientific meeting of the Italian Statistical Society
9788884678744
Ghiglietti, A., Paganoni, A. (2014). Statistical properties of urn designs in clinical trials. In 47th Scientific Meeting of the Italian Statistical Society Proceedings (pp.1-8). Cagliari : CUEC.
Ghiglietti, A; Paganoni, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/391738
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