In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes–macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.

Rasponi, M., Gazaneo, A., Bonomi, A., Ghiglietti, A., Occhetta, P., Fiore, G., et al. (2015). Lab-on-Chip for testing myelotoxic effect of drugs and chemicals. MICROFLUIDICS AND NANOFLUIDICS, 19(4), 935-940 [10.1007/s10404-015-1622-0].

Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

Ghiglietti, Andrea;
2015

Abstract

In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes–macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.
No
Articolo in rivista - Articolo scientifico
Scientifica
CB-MNC; CFU-GM; Clonogenic test; Lab-on-Chip; Microfluidics;
English
935
940
6
Rasponi, M., Gazaneo, A., Bonomi, A., Ghiglietti, A., Occhetta, P., Fiore, G., et al. (2015). Lab-on-Chip for testing myelotoxic effect of drugs and chemicals. MICROFLUIDICS AND NANOFLUIDICS, 19(4), 935-940 [10.1007/s10404-015-1622-0].
Rasponi, M; Gazaneo, A; Bonomi, A; Ghiglietti, A; Occhetta, P; Fiore, G; Pessina, A; Redaelli, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/391720
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