Background Heterogeneous results have been obtained regarding the presence of Target Organe Damage (TOD) in subjects with high-normal Blood Pressure (BP) value (sistoly 130–139, diastolic 85–89 mmHg). Purpose Aim of our study was to assess the prevalence of TOD in healthy subjects with high-normal BP comparing them with subjects with BP values that are considered normal (<130/85 mmHg) or indicative of hypertension (≥140/90 mmHg). Methods 755 otherwise healthy subjects participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Mass Index (LVMI) and carotid Intima-Media Thickness (IMT) and plaque. Results When subjects were classified according to BP levels we found that high-normal BP group showed intermediate values of PWV and LMVI with higher value of IMT. This corresponds to intermediate prevalence of arterial stiffness (PWV>10 m/s: 3.4% vs 2.3% for normal and 9.6% for high BP groups, p=0.0014), Left Ventricular Hypertrophy – LVH (32.4% vs 25.7% for normal and 46.6% for high BP groups, p=0.0001) while there were no differences for IMT>0.9 or carotid plaque. At multivariable analysis the odds of having a PWV>10 m/s (OR=1.75, 95% C.I. 0.59–5.16), an IMT>0.9 mm (OR=1.81, 95% C.I. 0.60–5.00) or a LVH (OR=1.1, 95% C.I. 0.72–1.67) in the high-normal group resulted not different to the normal group. Conclusions In our otherwise healthy population, high-normal BP values were not related to aortic, carotid or cardiac TOD.

Ruzzenenti, G., Maloberti, A., Rebora, P., Occhino, G., Alloni, M., Musca, F., et al. (2021). Prevalence of target organ damage in subjects with high-normal blood pressure without known cardiovascular and kidney disease. In ESC Congress 2021 – The Digital Experience 27 August – 30 August 2021 Abstract Supplement [10.1093/eurheartj/ehab724.2287].

Prevalence of target organ damage in subjects with high-normal blood pressure without known cardiovascular and kidney disease

Ruzzenenti, G;Maloberti, A;Rebora, P;Occhino, G;Alloni, M;Moreo, A;Valsecchi, M G;Giannattasio, C
2021

Abstract

Background Heterogeneous results have been obtained regarding the presence of Target Organe Damage (TOD) in subjects with high-normal Blood Pressure (BP) value (sistoly 130–139, diastolic 85–89 mmHg). Purpose Aim of our study was to assess the prevalence of TOD in healthy subjects with high-normal BP comparing them with subjects with BP values that are considered normal (<130/85 mmHg) or indicative of hypertension (≥140/90 mmHg). Methods 755 otherwise healthy subjects participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Mass Index (LVMI) and carotid Intima-Media Thickness (IMT) and plaque. Results When subjects were classified according to BP levels we found that high-normal BP group showed intermediate values of PWV and LMVI with higher value of IMT. This corresponds to intermediate prevalence of arterial stiffness (PWV>10 m/s: 3.4% vs 2.3% for normal and 9.6% for high BP groups, p=0.0014), Left Ventricular Hypertrophy – LVH (32.4% vs 25.7% for normal and 46.6% for high BP groups, p=0.0001) while there were no differences for IMT>0.9 or carotid plaque. At multivariable analysis the odds of having a PWV>10 m/s (OR=1.75, 95% C.I. 0.59–5.16), an IMT>0.9 mm (OR=1.81, 95% C.I. 0.60–5.00) or a LVH (OR=1.1, 95% C.I. 0.72–1.67) in the high-normal group resulted not different to the normal group. Conclusions In our otherwise healthy population, high-normal BP values were not related to aortic, carotid or cardiac TOD.
No
abstract + slide
Scientifica
metabolic syndrome , vessels
English
ESC Congress 2021 – The Digital Experience - 27 August – 30 August 2021
Ruzzenenti, G., Maloberti, A., Rebora, P., Occhino, G., Alloni, M., Musca, F., et al. (2021). Prevalence of target organ damage in subjects with high-normal blood pressure without known cardiovascular and kidney disease. In ESC Congress 2021 – The Digital Experience 27 August – 30 August 2021 Abstract Supplement [10.1093/eurheartj/ehab724.2287].
Ruzzenenti, G; Maloberti, A; Rebora, P; Occhino, G; Alloni, M; Musca, F; Belli, O; Spano', F; Santambrogio, G; Casadei, F; Moreo, A; Valsecchi, M; Giannattasio, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/391550
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