Magnetically driven nanosponges with potential application as targeted drug delivery systems were prepared via the addition of magnetite nanoparticles to the synthesis of cyclodextrin and maltodextrin polymers crosslinked with 1,1′-carbonyldiimidazole. The magnetic nanoparticles were obtained separately via a coprecipitation mechanism involving inorganic iron salts in an alkaline environment. Four composite nanosponges were prepared by varying the content of magnetic nanoparticles (5 wt% and 10 wt%) in the cyclodextrin-and maltodextrin-based polymer matrix. The magnetic nanosponges were then characterised by FTIR, TGA, XRD, FESEM, and HRTEM analysis. The magnetic properties of the nanosponges were investigated via magnetisation curves collected at RT. Finally, the magnetic nanosponges were loaded with doxorubicin and tested as a drug delivery system. The nanosponges exhibited a loading capacity of approximately 3 wt%. Doxorubicin was released by the loaded nanosponges with sustained kinetics over a prolonged period of time.

Caldera, F., Nistico', R., Magnacca, G., Matencio, A., Monfared, Y., Trotta, F. (2022). Magnetic composites of dextrin-based carbonate nanosponges and iron oxide nanoparticles with potential application in targeted drug delivery. NANOMATERIALS, 12(5), 1-14 [10.3390/nano12050754].

Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery

Nistico', R
Secondo
;
2022

Abstract

Magnetically driven nanosponges with potential application as targeted drug delivery systems were prepared via the addition of magnetite nanoparticles to the synthesis of cyclodextrin and maltodextrin polymers crosslinked with 1,1′-carbonyldiimidazole. The magnetic nanoparticles were obtained separately via a coprecipitation mechanism involving inorganic iron salts in an alkaline environment. Four composite nanosponges were prepared by varying the content of magnetic nanoparticles (5 wt% and 10 wt%) in the cyclodextrin-and maltodextrin-based polymer matrix. The magnetic nanosponges were then characterised by FTIR, TGA, XRD, FESEM, and HRTEM analysis. The magnetic properties of the nanosponges were investigated via magnetisation curves collected at RT. Finally, the magnetic nanosponges were loaded with doxorubicin and tested as a drug delivery system. The nanosponges exhibited a loading capacity of approximately 3 wt%. Doxorubicin was released by the loaded nanosponges with sustained kinetics over a prolonged period of time.
No
Articolo in rivista - Articolo scientifico
Scientifica
Cyclodextrin; Dextrin nanosponges; Doxorubicin; Iron oxide nanoparticles; Magnetic nanocomposites; Maltodextrin; Targeted drug delivery;
English
1
14
14
Caldera, F., Nistico', R., Magnacca, G., Matencio, A., Monfared, Y., Trotta, F. (2022). Magnetic composites of dextrin-based carbonate nanosponges and iron oxide nanoparticles with potential application in targeted drug delivery. NANOMATERIALS, 12(5), 1-14 [10.3390/nano12050754].
Caldera, F; Nistico', R; Magnacca, G; Matencio, A; Monfared, Y; Trotta, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/391513
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