Background: Late-onset (LO) and early-onset (EO) dementia show neurobiological and clinical differences. We compared clinical and FDG-PET features of LO and EO Posterior Cortical Atrophy (LO_PCA, EO_PCA), the visual variant of Alzheimer's Disease (AD). LO_PCA patients were also compared with a group of patients with LO typical AD (tAD). Methods: We recruited 37 LO_PCA patients (onset age > 65 years), 29 EO_PCA patients, and 40 tAD patients, who all underwent a standard neuropsychological battery; PCA patients were also assessed for the presence of posterior signs and symptoms. Brain FDG-PET was available in 32 LO_PCA cases, 23 EO_PCA cases and all tAD cases, and their scans were compared with scans from 30 healthy elderly controls. Within the entire PCA sample FDG uptake was also correlated with age at onset as continuous variable. Results: The main difference between the two PCA groups was a higher prevalence of Balint-Holmes symptoms in EO cases, which was associated with the presence of severe bilateral occipito-temporo-parietal hypometabolism, while LO_PCA patients showed reduction of FDG uptake mainly in the right posterior regions. This latter group also showed mesial temporal hypometabolism, similarly to the tAD group, although with a right rather than left lateralization. Correlation analysis confirmed the association between older age and decreased limbic metabolism, and younger age and decreased left parietal metabolism. Conclusions: The major involvement of the temporal cortex in LO cases and of the parietal cortex in EO cases reported previously within the AD spectrum holds true also for the visual variant of AD.

Isella, V., Licciardo, D., Nastasi, G., Impagnatiello, V., Ferri, F., Mapelli, C., et al. (2022). Clinical and metabolic imaging features of late-onset and early-onset Posterior Cortical Atrophy. EUROPEAN JOURNAL OF NEUROLOGY [10.1111/ene.15520].

Clinical and metabolic imaging features of late-onset and early-onset Posterior Cortical Atrophy

Isella, Valeria
Primo
;
Nastasi, Giulia;Ferri, Francesca;Mapelli, Cristina;Crivellaro, Cinzia;Morzenti, Sabrina;Appollonio, Ildebrando
Penultimo
;
Ferrarese, Carlo
Ultimo
2022

Abstract

Background: Late-onset (LO) and early-onset (EO) dementia show neurobiological and clinical differences. We compared clinical and FDG-PET features of LO and EO Posterior Cortical Atrophy (LO_PCA, EO_PCA), the visual variant of Alzheimer's Disease (AD). LO_PCA patients were also compared with a group of patients with LO typical AD (tAD). Methods: We recruited 37 LO_PCA patients (onset age > 65 years), 29 EO_PCA patients, and 40 tAD patients, who all underwent a standard neuropsychological battery; PCA patients were also assessed for the presence of posterior signs and symptoms. Brain FDG-PET was available in 32 LO_PCA cases, 23 EO_PCA cases and all tAD cases, and their scans were compared with scans from 30 healthy elderly controls. Within the entire PCA sample FDG uptake was also correlated with age at onset as continuous variable. Results: The main difference between the two PCA groups was a higher prevalence of Balint-Holmes symptoms in EO cases, which was associated with the presence of severe bilateral occipito-temporo-parietal hypometabolism, while LO_PCA patients showed reduction of FDG uptake mainly in the right posterior regions. This latter group also showed mesial temporal hypometabolism, similarly to the tAD group, although with a right rather than left lateralization. Correlation analysis confirmed the association between older age and decreased limbic metabolism, and younger age and decreased left parietal metabolism. Conclusions: The major involvement of the temporal cortex in LO cases and of the parietal cortex in EO cases reported previously within the AD spectrum holds true also for the visual variant of AD.
No
Articolo in rivista - Articolo scientifico
Scientifica
Alzheimer's Disease; FDG-PET; Posterior Cortical Atrophy; dementia; early-onset AD;
English
Isella, V., Licciardo, D., Nastasi, G., Impagnatiello, V., Ferri, F., Mapelli, C., et al. (2022). Clinical and metabolic imaging features of late-onset and early-onset Posterior Cortical Atrophy. EUROPEAN JOURNAL OF NEUROLOGY [10.1111/ene.15520].
Isella, V; Licciardo, D; Nastasi, G; Impagnatiello, V; Ferri, F; Mapelli, C; Crivellaro, C; Musarra, M; Morzenti, S; Appollonio, I; Ferrarese, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/390906
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