Objective: Sentinel lymph node mapping (SNM) has gained popularity in managing apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment. Methods: This is a multi-institutional retrospective study evaluating long-term outcomes of EC patients having nodal assessment between 01/01/2006 and 12/31/2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm. Results: Overall, 940 patients meeting inclusion criteria were included in the study, of which 174 (18.5%), 187 (19.9%), and 579 (61.6%) underwent SNM, SNM followed by backup lymphadenectomy (LND) and LND alone, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients, including 125 SNM, 125 SNM/backup LND, and 250 LND. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM/backup LND and LND, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p = 0.750) and overall survival (p = 0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification based on uterine risk factors. Conclusion: Our study highlighted that SNM provides similar long-term oncologic outcomes than LND.

Bogani, G., Di Donato, V., Papadia, A., Buda, A., Casarin, J., Multinu, F., et al. (2022). Evaluating long-term outcomes of three approaches to retroperitoneal staging in endometrial cancer. GYNECOLOGIC ONCOLOGY, 166(2 (August 2022)), 277-283 [10.1016/j.ygyno.2022.06.007].

Evaluating long-term outcomes of three approaches to retroperitoneal staging in endometrial cancer

Landoni, Fabio;
2022

Abstract

Objective: Sentinel lymph node mapping (SNM) has gained popularity in managing apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment. Methods: This is a multi-institutional retrospective study evaluating long-term outcomes of EC patients having nodal assessment between 01/01/2006 and 12/31/2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm. Results: Overall, 940 patients meeting inclusion criteria were included in the study, of which 174 (18.5%), 187 (19.9%), and 579 (61.6%) underwent SNM, SNM followed by backup lymphadenectomy (LND) and LND alone, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients, including 125 SNM, 125 SNM/backup LND, and 250 LND. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM/backup LND and LND, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p = 0.750) and overall survival (p = 0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification based on uterine risk factors. Conclusion: Our study highlighted that SNM provides similar long-term oncologic outcomes than LND.
Si
Articolo in rivista - Articolo scientifico
Scientifica
Endometrial cancer; Laparoscopy; Lymphadenectomy; Sentinel node mapping; Staging surgery;
English
277
283
7
Bogani, G., Di Donato, V., Papadia, A., Buda, A., Casarin, J., Multinu, F., et al. (2022). Evaluating long-term outcomes of three approaches to retroperitoneal staging in endometrial cancer. GYNECOLOGIC ONCOLOGY, 166(2 (August 2022)), 277-283 [10.1016/j.ygyno.2022.06.007].
Bogani, G; Di Donato, V; Papadia, A; Buda, A; Casarin, J; Multinu, F; Plotti, F; Cuccu, I; D'Auge, T; Gasparri, M; Pinelli, C; Perrone, A; Barra, F; Sorbi, F; Cromi, A; Di Martino, G; Palaia, I; Perniola, G; Ferrero, S; De Iaco, P; Perrone, C; Angioli, R; Luvero, D; Muzii, L; Ghezzi, F; Landoni, F; Mueller, M; Benedetti Panici, P; Raspagliesi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/390850
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