Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.

Bogani, G., Donato, V., Scambia, G., Landoni, F., Ghezzi, F., Muzii, L., et al. (2022). Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer. GYNECOLOGIC ONCOLOGY [10.1016/j.ygyno.2022.07.022].

Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

Landoni, Fabio;Landoni, Fabio;Di Martino, Giampaolo;Grassi, Tommaso;
2022

Abstract

Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.
No
Articolo in rivista - Articolo scientifico
Scientifica
Complications; Laparoscopy; Morbidity; Radical hysterectomy;
English
Bogani, G., Donato, V., Scambia, G., Landoni, F., Ghezzi, F., Muzii, L., et al. (2022). Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer. GYNECOLOGIC ONCOLOGY [10.1016/j.ygyno.2022.07.022].
Bogani, G; Donato, V; Scambia, G; Landoni, F; Ghezzi, F; Muzii, L; Panici, P; Raspagliesi, F; Bogani, G; Donato, V; Scambia, G; Ghezzi, F; Casarin, J; Landoni, F; Di Martino, G; Grassi, T; Perrone, A; De Iaco, P; Multinu, F; Berretta, R; Capozzi, V; Zupi, E; Centini, G; Pellegrino, A; Corso, S; Stevenazzi, G; Boschi, A; Comerci, G; Greco, P; Scutiero, G; Sopracordevole, F; Giorda, G; Fichera, M; Simoncini, T; Caretto, M; Sartori, E; Ferrari, F; Cianci, A; Sarpietro, G; Matarazzo, M; Giampaolino, P; Bifulco, G; Morelli, M; Dio, M; Ferrero, A; Biglia, N; Barra, F; Ferrero, S; Cianci, S; Chiantera, V; Ercoli, A; Schettini, S; Orlando, T; Cannone, F; Ettore, G; Puppo, A; Olearo, E; Maggiore, U; Artuso, V; Palaia, I; Perniola, G; Tripodi, R; D'Augè, T; Cuccu, I; Fischetti, M; Santangelo, G; Casorelli, A; Giannini, A; D'Oria, O; Vizzielli, G; Restaino, S; Bergamini, A; Bocciolone, L; Plotti, F; Angioli, R; Mantovani, G; Ceccaroni, M; Cassini, C; Dominoni, M; Giambanco, L; Amodeo, S; Leo, L; Thommaset, R; Raimondo, D; Serrachioli, R; Malzoni, M; Falcone, F; Gorlero, F; Di Luca, M; Busato, E; Kilzie, S; Dell'Acqua, A; Scarfone, G; Vercellini, P; Petrillo, M; Capobianco, G; Ciavattini, A; Mereu, L; Scollo, P; Sorbi, F; Fambrini, M; Romano, F; Ricci, G; Trojano, G; Damiani, G; Consonni, R; Di Lorenzo, N; Lippolis, A; Tinelli, R; Aguzzoli, L; Mandato, V; Palomba, S; Tripodi, M; Calandra, D; Pellegrini, F; Zullo, F; Surico, D; Remorgida, V; Ruscitto, F; Beretta, P; Vizza, E; Muzii, L; Panici, P; Raspagliesi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/390835
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