Background Mycosis fungoides (MF) is the most common and one of the least aggressive forms of cutaneous T-cell lymphoma. Several studies have demonstrated the influence of human leucocyte antigen (HLA) genes on the susceptibility of MF, highlighting the importance of certain alleles but, until today, no studies have evaluated the relationship between HLA alleles and the prognosis of patients with MF. Objectives The aim of this retrospective cohort study was to evaluate the polymorphism of HLA class I and class II alleles in a group of 46 MF Caucasian patients, looking for their influence in susceptibility and prognosis of the disease. Methods Study population included a case-cohort sample of 46 Caucasian patients with MF that, between 1993 and 1997, underwent HLA class I and II genomic typing. All patients were diagnosed and followed up from 1977 to 2012 (mean follow-up of 11 years) and they were divided into three groups according to the evolution of the disease. Results Molecular typing at low-resolution level revealed that HLA-A24, A68, A69, B35 and DQB105:02 alleles were involved in susceptibility to MF. Correspondence analysis underlined that long-lasting remission was characterized by HLA-A24 and HLA-A25 alleles, frequent relapse by HLA-DRB101, DQA101:01, DQB105:01 alleles and death by HLA-A68, HLA-B08, HLA-B35, HLA-C03 alleles. Conclusion This study suggests that the prognosis of MF patients is not only correlated with clinical/pathological/serological/immunological variables but it also relies on specific HLA alleles.

Brazzelli, V., Rivetti, N., Badulli, C., Carugno, A., Grasso, V., De Silvestri, A., et al. (2014). Immunogenetic factors in mycosis fungoides: Can the HLA system influence the susceptibility and prognosis of the disease? Long-term follow-up study of 46 patients. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 28(12), 1732-1737 [10.1111/jdv.12391].

Immunogenetic factors in mycosis fungoides: Can the HLA system influence the susceptibility and prognosis of the disease? Long-term follow-up study of 46 patients

Carugno A.;
2014

Abstract

Background Mycosis fungoides (MF) is the most common and one of the least aggressive forms of cutaneous T-cell lymphoma. Several studies have demonstrated the influence of human leucocyte antigen (HLA) genes on the susceptibility of MF, highlighting the importance of certain alleles but, until today, no studies have evaluated the relationship between HLA alleles and the prognosis of patients with MF. Objectives The aim of this retrospective cohort study was to evaluate the polymorphism of HLA class I and class II alleles in a group of 46 MF Caucasian patients, looking for their influence in susceptibility and prognosis of the disease. Methods Study population included a case-cohort sample of 46 Caucasian patients with MF that, between 1993 and 1997, underwent HLA class I and II genomic typing. All patients were diagnosed and followed up from 1977 to 2012 (mean follow-up of 11 years) and they were divided into three groups according to the evolution of the disease. Results Molecular typing at low-resolution level revealed that HLA-A24, A68, A69, B35 and DQB105:02 alleles were involved in susceptibility to MF. Correspondence analysis underlined that long-lasting remission was characterized by HLA-A24 and HLA-A25 alleles, frequent relapse by HLA-DRB101, DQA101:01, DQB105:01 alleles and death by HLA-A68, HLA-B08, HLA-B35, HLA-C03 alleles. Conclusion This study suggests that the prognosis of MF patients is not only correlated with clinical/pathological/serological/immunological variables but it also relies on specific HLA alleles.
Articolo in rivista - Articolo scientifico
HLA system, Mycosis fungoides
English
1732
1737
6
Brazzelli, V., Rivetti, N., Badulli, C., Carugno, A., Grasso, V., De Silvestri, A., et al. (2014). Immunogenetic factors in mycosis fungoides: Can the HLA system influence the susceptibility and prognosis of the disease? Long-term follow-up study of 46 patients. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 28(12), 1732-1737 [10.1111/jdv.12391].
Brazzelli, V; Rivetti, N; Badulli, C; Carugno, A; Grasso, V; De Silvestri, A; Martinetti, M; Borroni, G
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/390707
Citazioni
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 6
Social impact