PRIMA project is an Italian project funded by INFN and MIUR (PRIN 2006), which developed a proton Computed Tomography (pCT) prototype based on tracking the single proton. PRIMA approaches to the pCT consist in the use of silicon detectors, which measure the energy and position of individual protons before and after they traverse the object. The device consists of a silicon microstrip tracker, used to reconstruct the trajectory of each proton, and a calorimeter that measure the particle residual energy. It is characterized by an active area of 5 × 5 cm2 and by an acquisition rate of 10kHz. PRIMA prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography images, were carried out during these beam tests. In particular in this paper will be reported the PRIMA experience on the data acquired using special phantoms. The performed tests aimed to evaluate the clinical applicability of proton radiography in terms of image quality. In order to test spatial resolution, electron density resolution and energy resolution of the system, PRIMA group has developed suitable phantoms for radiography. The phantoms are custom-made and suitable for high-contrast spatial resolution. They are PolyMetilMetacrilate (PMMA) cylinders with holes of different size and depth. In particular, the phantom diameter was chosen accordingly with the tracker field of view while the phantom length depends on the beam quality: it was 20mm and 150mm for 60MeV and 180MeV proton beam respectively. In this paper the experimental setup will be described, radiographic images will be shown and quantitative results on spatial resolution will be reported.

Talamonti, C., Bruzzi, M., Bucciolini, M., Carpinelli, M., Cirrone, G., Civinini, C., et al. (2012). PRIMA Proton Imaging for Clinical Application. In 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 (pp.2218-2221).

PRIMA Proton Imaging for Clinical Application

CARPINELLI, Massimo;
2012

Abstract

PRIMA project is an Italian project funded by INFN and MIUR (PRIN 2006), which developed a proton Computed Tomography (pCT) prototype based on tracking the single proton. PRIMA approaches to the pCT consist in the use of silicon detectors, which measure the energy and position of individual protons before and after they traverse the object. The device consists of a silicon microstrip tracker, used to reconstruct the trajectory of each proton, and a calorimeter that measure the particle residual energy. It is characterized by an active area of 5 × 5 cm2 and by an acquisition rate of 10kHz. PRIMA prototype was tested, under 62 MeV proton beam at Laboratory Nazionali del Sud, (Catania Italy) and under 180 MeV proton beam at Svedberg Laboratories, Uppsala Universitet, (Uppsala Sweden). Several experiments concerning proton imaging, tomography and radiography images, were carried out during these beam tests. In particular in this paper will be reported the PRIMA experience on the data acquired using special phantoms. The performed tests aimed to evaluate the clinical applicability of proton radiography in terms of image quality. In order to test spatial resolution, electron density resolution and energy resolution of the system, PRIMA group has developed suitable phantoms for radiography. The phantoms are custom-made and suitable for high-contrast spatial resolution. They are PolyMetilMetacrilate (PMMA) cylinders with holes of different size and depth. In particular, the phantom diameter was chosen accordingly with the tracker field of view while the phantom length depends on the beam quality: it was 20mm and 150mm for 60MeV and 180MeV proton beam respectively. In this paper the experimental setup will be described, radiographic images will be shown and quantitative results on spatial resolution will be reported.
Si
paper
Computerized tomography; Data privacy; Image resolution; Medical imaging; Nuclear physics; Optical microscopy; Polymethyl methacrylates; Proton beams; Protons; Radiography; Clinical application; Energy resolutions; Proton computed tomography (pCT); Quantitative result; Radiographic images; Radiography images; Silicon microstrip trackers; Spatial resolution; Network security;
English
2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 - 29 October 2012 through 3 November 2012
978-1-4673-2030-6
Talamonti, C., Bruzzi, M., Bucciolini, M., Carpinelli, M., Cirrone, G., Civinini, C., et al. (2012). PRIMA Proton Imaging for Clinical Application. In 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 (pp.2218-2221).
Talamonti, C; Bruzzi, M; Bucciolini, M; Carpinelli, M; Cirrone, G; Civinini, C; Cuttone, G; Lo Presti, D; Pallotta, S; Randazzo, N; Romano, F; Scaringella, M; Sipala, V; Stancampiano, C; Vanzi, E; Zani, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/389551
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