Ten patients with essential cryoglobulinaemia type II were examined for peripheral nerve damage. In six cases distal symmetrical nerve involvement was present, while in three other cases abnormalities restricted to single nerves were found. Electrophysiological and morphological data were consistent with axonal damage, the larger myelinated fibres being most affected. Although active signs of vasculitis and immunoperoxidase staining for immunoglobulins were not present, endoneurial vessels were widely damaged, with abnormally thick endothelial cells and redundant basal membranes. These findings, together with a patchy distribution of myelinated fibre loss, suggest ischaemia as a cause of peripheral neuropathy during essential cryoglobulinaemia type II. A follow up examination, performed one year after haematologial remission, revealed that no further peripheral nerve damage had occurred

Cavaletti, G., Petruccioli, M., Crespi, V., Pioltelli, P., Marmiroli, P., Tredici, G. (1990). A clinico-pathological and follow up study of 10 cases of essential type II cryoglobulinaemic neuropathy. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 53(10), 886-889 [10.1136/jnnp.53.10.886].

A clinico-pathological and follow up study of 10 cases of essential type II cryoglobulinaemic neuropathy

CAVALETTI, GUIDO ANGELO;MARMIROLI, PAOLA LORENA;TREDICI, GIOVANNI
1990

Abstract

Ten patients with essential cryoglobulinaemia type II were examined for peripheral nerve damage. In six cases distal symmetrical nerve involvement was present, while in three other cases abnormalities restricted to single nerves were found. Electrophysiological and morphological data were consistent with axonal damage, the larger myelinated fibres being most affected. Although active signs of vasculitis and immunoperoxidase staining for immunoglobulins were not present, endoneurial vessels were widely damaged, with abnormally thick endothelial cells and redundant basal membranes. These findings, together with a patchy distribution of myelinated fibre loss, suggest ischaemia as a cause of peripheral neuropathy during essential cryoglobulinaemia type II. A follow up examination, performed one year after haematologial remission, revealed that no further peripheral nerve damage had occurred
Articolo in rivista - Articolo scientifico
cryoglobulinemia; peripheral neuropathy; ischaemia;
English
886
889
4
Cavaletti, G., Petruccioli, M., Crespi, V., Pioltelli, P., Marmiroli, P., Tredici, G. (1990). A clinico-pathological and follow up study of 10 cases of essential type II cryoglobulinaemic neuropathy. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 53(10), 886-889 [10.1136/jnnp.53.10.886].
Cavaletti, G; Petruccioli, M; Crespi, V; Pioltelli, P; Marmiroli, P; Tredici, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/38902
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