In an unselected series of patients with monoclonal gammopathy of undetermined significance (MGUS) we found neuropathy in 2 of 34 patients with IgG (6%), 2 of 14 with IgA (14%), and 8 of 26 with IgM MGUS (31%). The neuropathy was subclinical in 6 patients (1 IgG, 1 IgA, and 4 IgM). Patients with IgG or IgA MGUS had a prominent motor impairment with electrophysiologic and morphologic findings suggestive of predominant axonal degeneration. No deposit of the M-protein in sural nerve and no reactivity of the M-protein with nerve was detected in these patients. Patients with IgM MGUS had a prominent sensory impairment with evidence of predominant demyelination. In 6 of these patients the M-protein reacted with the myelin-associated glycoprotein (MAG). The higher prevalence of neuropathy in patients with IgM MGUS may be related to the frequent reactivity of IgM M-proteins with MAG

Nobile Orazio, E., Barbieri, S., Baldini, L., Marmiroli, P., Carpo, M., Premoselli, S., et al. (1992). Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies. ACTA NEUROLOGICA SCANDINAVICA, 85(6), 383-390 [10.1111/j.1600-0404.1992.tb06033.x].

Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies

MARMIROLI, PAOLA LORENA;
1992

Abstract

In an unselected series of patients with monoclonal gammopathy of undetermined significance (MGUS) we found neuropathy in 2 of 34 patients with IgG (6%), 2 of 14 with IgA (14%), and 8 of 26 with IgM MGUS (31%). The neuropathy was subclinical in 6 patients (1 IgG, 1 IgA, and 4 IgM). Patients with IgG or IgA MGUS had a prominent motor impairment with electrophysiologic and morphologic findings suggestive of predominant axonal degeneration. No deposit of the M-protein in sural nerve and no reactivity of the M-protein with nerve was detected in these patients. Patients with IgM MGUS had a prominent sensory impairment with evidence of predominant demyelination. In 6 of these patients the M-protein reacted with the myelin-associated glycoprotein (MAG). The higher prevalence of neuropathy in patients with IgM MGUS may be related to the frequent reactivity of IgM M-proteins with MAG
Articolo in rivista - Articolo scientifico
neuropathy; monoclonal gammopathy; myelin-associated glycoprotein
English
383
390
8
Nobile Orazio, E., Barbieri, S., Baldini, L., Marmiroli, P., Carpo, M., Premoselli, S., et al. (1992). Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies. ACTA NEUROLOGICA SCANDINAVICA, 85(6), 383-390 [10.1111/j.1600-0404.1992.tb06033.x].
Nobile Orazio, E; Barbieri, S; Baldini, L; Marmiroli, P; Carpo, M; Premoselli, S; Manfredini, E; Scarlato, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/38893
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