The introduction of protease inhibitors has proven a watershed in human immunodeficiency virus infection therapy and has initiated an era of highly active anti-retroviral therapy. However, the numerous data on the effectiveness of these therapeutic regimens have been cited with an ever-growing number of communications concerning adverse reactions. In particular, the widescale use of protease inhibitors has underlined a series of events not evidenced in the controlled clinical studies that permitted the registration of these drugs. We are conducting a cohort multicenter study to evaluate the incidence of adverse events during treatment with protease inhibitors. To date, 4 cases of bilateral osteonecrosis of the femoral head have been reported out of 1073 person-years. While the pathogenesis of this event is unclear, it may be a long-term complication of protease inhibitor treatment.

Bonfanti, P., Grabbuti, A., Carradori, S., Pusterla, L., Parrazini, F., Landonio, S., et al. (2001). Osteonecrosis in protease inhibitor-treated patients. ORTHOPEDICS, 24(3), 271-272 [10.3928/0147-7447-20010301-19].

Osteonecrosis in protease inhibitor-treated patients

Bonfanti, P;
2001

Abstract

The introduction of protease inhibitors has proven a watershed in human immunodeficiency virus infection therapy and has initiated an era of highly active anti-retroviral therapy. However, the numerous data on the effectiveness of these therapeutic regimens have been cited with an ever-growing number of communications concerning adverse reactions. In particular, the widescale use of protease inhibitors has underlined a series of events not evidenced in the controlled clinical studies that permitted the registration of these drugs. We are conducting a cohort multicenter study to evaluate the incidence of adverse events during treatment with protease inhibitors. To date, 4 cases of bilateral osteonecrosis of the femoral head have been reported out of 1073 person-years. While the pathogenesis of this event is unclear, it may be a long-term complication of protease inhibitor treatment.
Articolo in rivista - Articolo scientifico
Adult; Cohort Studies; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; Humans; Incidence; Male; Osteonecrosis; Risk Assessment;
English
271
272
2
Bonfanti, P., Grabbuti, A., Carradori, S., Pusterla, L., Parrazini, F., Landonio, S., et al. (2001). Osteonecrosis in protease inhibitor-treated patients. ORTHOPEDICS, 24(3), 271-272 [10.3928/0147-7447-20010301-19].
Bonfanti, P; Grabbuti, A; Carradori, S; Pusterla, L; Parrazini, F; Landonio, S; Quirino, T
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/388147
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