to correlate cerebral histopathological and immunohistochemical changes in the neuroclinical features of the AIDS dementia complex(ADC), autopsy results of 28 ADC patients were related, in a retrospective analysis, to scores on a standardised neurological examination performed at neurological onset. from a histopathological point of view, the cases were classified as follows: 9 cases of HIV leucoencephalopathy (HIVL; diffuse myelin damage and rare microglial nodules), 7 cases of HIV encephalitis (HIVE; several microglial nodules and no myelin damage) and 12 cases of mixed HIVL and HIVE (HIVL-E). The groups differed significantly with respect to symptoms and CD4 count at neurological onset, survival and neurological impairment. Immunohistochemically, the interstitial component (p-24-positive cells scattered singly within the white matter) was significantly more prevalent in HIVL, and the micronodular component (P24-positive cells confined within microglial nodules) in HIVE. Neurological damage was worse in cases with a high prevalence of interstitial component or a low prevalence of micronodular component. HIVE, HIVL, and HIVL-E are distinct clinical forms of ADC. Neurological impairmente is related to white matter damage.
Grassi, M., Clerici, F., Vago, L., Perin, C., Borella, M., Nebuloni, M., et al. (2002). Clinical Aspects of the AIDS dementia-Complex in Relation to Histopathological and Immunohistochemical variables. EUROPEAN NEUROLOGY, 47, 141-147.
Clinical Aspects of the AIDS dementia-Complex in Relation to Histopathological and Immunohistochemical variables
PERIN, CECILIA;
2002
Abstract
to correlate cerebral histopathological and immunohistochemical changes in the neuroclinical features of the AIDS dementia complex(ADC), autopsy results of 28 ADC patients were related, in a retrospective analysis, to scores on a standardised neurological examination performed at neurological onset. from a histopathological point of view, the cases were classified as follows: 9 cases of HIV leucoencephalopathy (HIVL; diffuse myelin damage and rare microglial nodules), 7 cases of HIV encephalitis (HIVE; several microglial nodules and no myelin damage) and 12 cases of mixed HIVL and HIVE (HIVL-E). The groups differed significantly with respect to symptoms and CD4 count at neurological onset, survival and neurological impairment. Immunohistochemically, the interstitial component (p-24-positive cells scattered singly within the white matter) was significantly more prevalent in HIVL, and the micronodular component (P24-positive cells confined within microglial nodules) in HIVE. Neurological damage was worse in cases with a high prevalence of interstitial component or a low prevalence of micronodular component. HIVE, HIVL, and HIVL-E are distinct clinical forms of ADC. Neurological impairmente is related to white matter damage.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.