This review systematically analyses recent knowledge of the biology of the growth hormone-releasing peptides. Many years before native GHRH had been isolated and sequenced, the synthesis of an enkephalin analog, devoid of any opioid activity but capable of specifically releasing GH from in vitro pituitaries, prompted the design of a number of structurally interrelated GHRPs with improved GH-releasing activity. Nowadays, GHRPs are the most effective GH-secretagogues known and could be used profitably in humans with GH hyposecretory disturbances to promote a pattern of GH secretion that mimics physiology in a better way than the exogenously administered GH.

Locatelli, V., & Torsello, A. (1997). Growth hormone secretagogues: focus on the growth hormone-releasing peptides. PHARMACOLOGICAL RESEARCH, 36(6), 415-423 [10.1006/phrs.1997.0253].

Growth hormone secretagogues: focus on the growth hormone-releasing peptides

LOCATELLI, VITTORIO;TORSELLO, ANTONIO BIAGIO
1997-12

Abstract

This review systematically analyses recent knowledge of the biology of the growth hormone-releasing peptides. Many years before native GHRH had been isolated and sequenced, the synthesis of an enkephalin analog, devoid of any opioid activity but capable of specifically releasing GH from in vitro pituitaries, prompted the design of a number of structurally interrelated GHRPs with improved GH-releasing activity. Nowadays, GHRPs are the most effective GH-secretagogues known and could be used profitably in humans with GH hyposecretory disturbances to promote a pattern of GH secretion that mimics physiology in a better way than the exogenously administered GH.
Recensione in rivista
Scientifica
Animals; Hypothalamus; Human Growth Hormone; Growth Substances; Humans; Pituitary Gland, Anterior; Drug Design; Receptors, Cell Surface; Somatostatin; Structure-Activity Relationship; Calcium Channels; RNA, Messenger; Growth Hormone-Releasing Hormone; Oligopeptides; Enkephalins
English
Locatelli, V., & Torsello, A. (1997). Growth hormone secretagogues: focus on the growth hormone-releasing peptides. PHARMACOLOGICAL RESEARCH, 36(6), 415-423 [10.1006/phrs.1997.0253].
Locatelli, V; Torsello, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/38455
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