Through its ability to regulate the activity of a large number of transcription factors, the Ras pathway is able to control several transcriptional programs leading to proliferation, differentiation, metabolism, cytoskeletal reorganization and immune response. Cyclic AMP (cAMP) is a ubiquitous intracellular second messenger whose major intracellular target in eukaryotes is protein kinase A (PKA). Wide evidence for cross talk between the Ras and cAMP-PKA pathways is available. After reviewing some features of Ras and PKA signalling that are relevant for cancer biology, we re-analyze available genome-wide expression data for genes encoding proteins of the downstream branch of the PKA pathway in human tumor cell lines as a function of the mutational state of the Ras pathway. The observed Ras-dependent pattern of regulation of the analyzed genes may contribute to explain how the cAMP-PKA axis is involved in oncogenic processes induced by Ras.

Chiaradonna, F., Balestrieri, C., Gaglio, D., Vanoni, M. (2008). RAS and PKA pathways in cancer: new insight from transcriptional analysis. FRONTIERS IN BIOSCIENCE, 13(14), 5257-5278 [10.2741/3079].

RAS and PKA pathways in cancer: new insight from transcriptional analysis

CHIARADONNA, FERDINANDO;BALESTRIERI, CHIARA;GAGLIO, DANIELA;VANONI, MARCO ERCOLE
2008

Abstract

Through its ability to regulate the activity of a large number of transcription factors, the Ras pathway is able to control several transcriptional programs leading to proliferation, differentiation, metabolism, cytoskeletal reorganization and immune response. Cyclic AMP (cAMP) is a ubiquitous intracellular second messenger whose major intracellular target in eukaryotes is protein kinase A (PKA). Wide evidence for cross talk between the Ras and cAMP-PKA pathways is available. After reviewing some features of Ras and PKA signalling that are relevant for cancer biology, we re-analyze available genome-wide expression data for genes encoding proteins of the downstream branch of the PKA pathway in human tumor cell lines as a function of the mutational state of the Ras pathway. The observed Ras-dependent pattern of regulation of the analyzed genes may contribute to explain how the cAMP-PKA axis is involved in oncogenic processes induced by Ras.
Articolo in rivista - Articolo scientifico
CANCER, RAS, PKA, TRANSCRIPTIONAL DATA
English
2008
13
14
5257
5278
none
Chiaradonna, F., Balestrieri, C., Gaglio, D., Vanoni, M. (2008). RAS and PKA pathways in cancer: new insight from transcriptional analysis. FRONTIERS IN BIOSCIENCE, 13(14), 5257-5278 [10.2741/3079].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/3841
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