Nuchal fold thickness is the best ultrasonographic predictor of fetal trisomy 21. However, the risk assigned on the basis of the commonly used threshold of nuchal fold thickness >/=6 mm does not take into consideration the significant associations between nuchal fold thickness and gestational age and between maternal age and Down syndrome. We propose a new method of calculating Down syndrome probability that takes into account both gestational age at examination and previously assessed probability of Down syndrome.
Locatelli, A., Piccoli, M., Vergani, P., Mariani, E., Ghidini, A., Mariani, S., et al. (2000). Critical appraisal of the use of nuchal fold thickness measurements for the prediction of Down syndrome. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 182(1 Pt 1), 192-197 [10.1016/S0002-9378(00)70512-6].
Critical appraisal of the use of nuchal fold thickness measurements for the prediction of Down syndrome
LOCATELLI, ANNA;VERGANI, PATRIZIA;
2000
Abstract
Nuchal fold thickness is the best ultrasonographic predictor of fetal trisomy 21. However, the risk assigned on the basis of the commonly used threshold of nuchal fold thickness >/=6 mm does not take into consideration the significant associations between nuchal fold thickness and gestational age and between maternal age and Down syndrome. We propose a new method of calculating Down syndrome probability that takes into account both gestational age at examination and previously assessed probability of Down syndrome.
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