Growth hormone-releasing peptides (GHRPs) are a class of small peptides that stimulate growth hormone (GH) release in several animal species, including the human. Moreover, GHRPs injected into the brain ventricles stimulate feeding in the rat. The aim of this study was to evaluate the GH-releasing properties of a series of novel GHRP analogs and the possible existence of functional correlations between the GH-releasing activity and the effects on feeding behavior. Two well-known hexapeptides, GHRP-6 and hexarelin, given s.c., dose dependently stimulated both GH release and feeding behavior in satiated rats. However, in a series of tri-, penta- and hexapeptide analogs of hexarelin, some compounds were active either on GH release or on eating behavior. Interestingly, even minor structural modifications resulted in major changes of the pharmacological profile. We conclude that GHRPs have orexigenic properties after systemic administration which are largely independent from the effects they exert on GH release.

Torsello, A., Luoni, M., Schweiger, F., Grilli, R., Guidi, M., Bresciani, E., et al. (1998). Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. EUROPEAN JOURNAL OF PHARMACOLOGY, 360(2-3), 123-129 [10.1016/S0014-2999(98)00677-3].

Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release

TORSELLO, ANTONIO BIAGIO;BRESCIANI, ELENA;LOCATELLI, VITTORIO
1998

Abstract

Growth hormone-releasing peptides (GHRPs) are a class of small peptides that stimulate growth hormone (GH) release in several animal species, including the human. Moreover, GHRPs injected into the brain ventricles stimulate feeding in the rat. The aim of this study was to evaluate the GH-releasing properties of a series of novel GHRP analogs and the possible existence of functional correlations between the GH-releasing activity and the effects on feeding behavior. Two well-known hexapeptides, GHRP-6 and hexarelin, given s.c., dose dependently stimulated both GH release and feeding behavior in satiated rats. However, in a series of tri-, penta- and hexapeptide analogs of hexarelin, some compounds were active either on GH release or on eating behavior. Interestingly, even minor structural modifications resulted in major changes of the pharmacological profile. We conclude that GHRPs have orexigenic properties after systemic administration which are largely independent from the effects they exert on GH release.
Articolo in rivista - Articolo scientifico
Scientifica
Rats; Animals; Rats, Sprague-Dawley; Growth Substances; Feeding Behavior; Oligopeptides; Male; Growth Hormone
English
Torsello, A., Luoni, M., Schweiger, F., Grilli, R., Guidi, M., Bresciani, E., et al. (1998). Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. EUROPEAN JOURNAL OF PHARMACOLOGY, 360(2-3), 123-129 [10.1016/S0014-2999(98)00677-3].
Torsello, A; Luoni, M; Schweiger, F; Grilli, R; Guidi, M; Bresciani, E; Deghenghi, R; Müller, E; Locatelli, V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/38261
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