OBJECTIVE - To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN ANDMETHODS - Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS - During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The finalmodel demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS - Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures. © 2011 by the American Diabetes Association.

Brambilla, P., La Valle, E., Falbo, R., Limonta, G., Signorini, S., Cappellini, F., et al. (2011). Normal fasting plasma glucose and risk of type 2 diabetes. DIABETES CARE, 34(6), 1372-1374 [10.2337/dc10-2263].

Normal fasting plasma glucose and risk of type 2 diabetes

BRAMBILLA, PAOLO;
2011

Abstract

OBJECTIVE - To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN ANDMETHODS - Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS - During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The finalmodel demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS - Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures. © 2011 by the American Diabetes Association.
Articolo in rivista - Articolo scientifico
Humans; Retrospective Studies; Aged; Fasting; Italy; Blood Glucose; Risk; Adult; Diabetes Mellitus, Type 2; Incidence; Middle Aged; Female; Male; Proportional Hazards Models
English
2011
34
6
1372
1374
open
Brambilla, P., La Valle, E., Falbo, R., Limonta, G., Signorini, S., Cappellini, F., et al. (2011). Normal fasting plasma glucose and risk of type 2 diabetes. DIABETES CARE, 34(6), 1372-1374 [10.2337/dc10-2263].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/38228
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