Human fibroblasts in culture have been employed as an in vitro system to investigate some pathophysiological mechanisms of diabetes mellitus also associated with the development of diabetic nephropathy. In fact, there is increasing evidence that genetic factors either convey the risk of, or protect from, diabetic nephropathy and that the expression profiles and/or the behaviour of the cultured skin fibroblasts from type 1 diabetic patients could reflect these genetic influences. On the other hand, alterations could be attributable not only to changes in DNA sequence, but also to epigenetic factors. Our aim is to make a critical overview of the studies involving primary cultures of skin fibroblasts as tools to investigate the pathophysiology of diabetic nephropathy performed until now in this area. Cultured skin fibroblasts could be useful not only for the identification of patients at risk of developing diabetic renal disease, but also for a better understanding of the complex multifactorial mechanisms leading to the long-term complications in diabetes.

Millioni, R., Puricelli, L., Iori, E., Trevisan, R., Tessari, P. (2012). Skin fibroblasts as a tool for identifying the risk of nephropathy in the type 1 diabetic population. DIABETES/METABOLISM RESEARCH AND REVIEWS, 28(1), 62-70 [10.1002/dmrr.1287].

Skin fibroblasts as a tool for identifying the risk of nephropathy in the type 1 diabetic population

Trevisan R;
2012

Abstract

Human fibroblasts in culture have been employed as an in vitro system to investigate some pathophysiological mechanisms of diabetes mellitus also associated with the development of diabetic nephropathy. In fact, there is increasing evidence that genetic factors either convey the risk of, or protect from, diabetic nephropathy and that the expression profiles and/or the behaviour of the cultured skin fibroblasts from type 1 diabetic patients could reflect these genetic influences. On the other hand, alterations could be attributable not only to changes in DNA sequence, but also to epigenetic factors. Our aim is to make a critical overview of the studies involving primary cultures of skin fibroblasts as tools to investigate the pathophysiology of diabetic nephropathy performed until now in this area. Cultured skin fibroblasts could be useful not only for the identification of patients at risk of developing diabetic renal disease, but also for a better understanding of the complex multifactorial mechanisms leading to the long-term complications in diabetes.
Articolo in rivista - Articolo scientifico
Diabetic nephropathy; Skin fibroblasts;
English
62
70
9
Millioni, R., Puricelli, L., Iori, E., Trevisan, R., Tessari, P. (2012). Skin fibroblasts as a tool for identifying the risk of nephropathy in the type 1 diabetic population. DIABETES/METABOLISM RESEARCH AND REVIEWS, 28(1), 62-70 [10.1002/dmrr.1287].
Millioni, R; Puricelli, L; Iori, E; Trevisan, R; Tessari, P
File in questo prodotto:
File Dimensione Formato  
Skin_fibroblasts_tool_2012.pdf

Solo gestori archivio

Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Dimensione 113.9 kB
Formato Adobe PDF
113.9 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/382198
Citazioni
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 8
Social impact