Various studies suggested that inflammation is involved in the pathogenesis of Alzheimer's disease (AD). We investigated cytokine release from LPS-stimulated blood cells of 32 AD patients, with different disease severity, compared to 16 age-related controls. A significant decrease of IL-1beta and IL-6 secretion was observed in severely demented patients; TNF-alpha release was also decreased, but not significantly. By contrast, mild and moderate patients showed a cytokine release similar to controls. IL-1beta, IL-6 and TNF-alpha secretion was negatively correlated with the severity of dementia, quantified by the MMSE. Our data suggest that alterations of the immune profile are associated with AD progression.

Sala, G., Galimberti, G., Canevari, C., Raggi, M., Isella, V., Facheris, M., et al. (2003). Peripheral cytokine release in Alzheimer patients: correlation with disease severity. NEUROBIOLOGY OF AGING, 24(7), 909-914 [10.1016/S0197-4580(03)00010-1].

Peripheral cytokine release in Alzheimer patients: Correlation with disease severity

SALA, GESSICA;GALIMBERTI, GLORIA;CANEVARI, CARLA;ISELLA, VALERIA;FACHERIS, MAURIZIO;APPOLLONIO, ILDEBRANDO;FERRARESE, CARLO
2003

Abstract

Various studies suggested that inflammation is involved in the pathogenesis of Alzheimer's disease (AD). We investigated cytokine release from LPS-stimulated blood cells of 32 AD patients, with different disease severity, compared to 16 age-related controls. A significant decrease of IL-1beta and IL-6 secretion was observed in severely demented patients; TNF-alpha release was also decreased, but not significantly. By contrast, mild and moderate patients showed a cytokine release similar to controls. IL-1beta, IL-6 and TNF-alpha secretion was negatively correlated with the severity of dementia, quantified by the MMSE. Our data suggest that alterations of the immune profile are associated with AD progression.
No
Articolo in rivista - Articolo scientifico
Scientifica
Alzheimer, demenza, citochine, TNF, Aged; Aged, 80 and over; Aging; Alzheimer Disease; Biological Markers; Cortisone; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-6; Lymphocyte Activation; Lymphocytes; Male; Matched-Pair Analysis; Middle Aged; Neuropsychological Tests; Severity of Illness Index; Statistics as Topic; Tumor Necrosis Factor-alpha
English
Sala, G., Galimberti, G., Canevari, C., Raggi, M., Isella, V., Facheris, M., et al. (2003). Peripheral cytokine release in Alzheimer patients: correlation with disease severity. NEUROBIOLOGY OF AGING, 24(7), 909-914 [10.1016/S0197-4580(03)00010-1].
Sala, G; Galimberti, G; Canevari, C; Raggi, M; Isella, V; Facheris, M; Appollonio, I; Ferrarese, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/3816
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