Protein phosphorylation is a major regulatory mechanism that controls many players in several basic cellular processes, indeed it is estimated that 30% of the proteome is subjected to phosphorylation. The phosphorylated state of a protein is a balance between the action of protein kinases and protein phosphatases that act on the same substrate. The phosphorylated state of a protein can change its fate in terms of subcellular localization, activity or stability. In this review we will focus on some examples of proteins that are regulated by phosphorylation and involved in the control of cell cycle progression, mitosis and cytokinesis in Saccharomyces cerevisiae.
Fraschini, R., Raspelli, E., Cassani, C. (2012). Protein Phosphorylation is an Important Tool to Change the Fate of Key Players in the Control of Cell Cycle Progression in Saccharomyces cerevisiae. In C. Huang (a cura di), Protein Phosphorylation in Human Health (pp. 377-394). Rijeka : InTech [10.5772/47809].
Protein Phosphorylation is an Important Tool to Change the Fate of Key Players in the Control of Cell Cycle Progression in Saccharomyces cerevisiae
FRASCHINI, ROBERTA;RASPELLI, ERICA;CASSANI, CORINNE
2012
Abstract
Protein phosphorylation is a major regulatory mechanism that controls many players in several basic cellular processes, indeed it is estimated that 30% of the proteome is subjected to phosphorylation. The phosphorylated state of a protein is a balance between the action of protein kinases and protein phosphatases that act on the same substrate. The phosphorylated state of a protein can change its fate in terms of subcellular localization, activity or stability. In this review we will focus on some examples of proteins that are regulated by phosphorylation and involved in the control of cell cycle progression, mitosis and cytokinesis in Saccharomyces cerevisiae.
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